Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366630 | 0.89 | AR (0.69) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL4358795 | 0.89 | AR (0.76) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL16012391 | 0.86 | KDM4E (0.62) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL4362358 | 0.85 | AR (0.67) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL6613726 | 0.84 | AR (0.59) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL4361748 | 0.82 | AR (0.63) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL14759252 | 0.81 | AR (0.62) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL5082108 | 0.81 | AR (1.00) | ARCYP3A4MAPTMAPK1CYP19A1 | |
| SCHEMBL4358326 | 0.80 | AR (0.63) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL16012836 | 0.79 | ESR2 (0.56) | ARCYP3A4MAPTMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166548-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | SANOFI (FR) | 2017-06-15 | — | — | US | disclosed |
| EP-2964623-B1 | SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2016-11-02 | — | — | EP | disclosed |
| US-9440941-B2 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | SANOFI (FR) | 2016-09-13 | — | — | US | disclosed |
| US-20160016928-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | SANOFI (FR) | 2016-01-21 | — | — | US | disclosed |
| EP-2964623-A1 | SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135674-A1 | SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2014-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016928-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | RYR2, RYR1, CACNA1E | AR 912/4885CYP3A4 1023/4885MAPT 3715/4885 |
| US-20170166548-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | RYR2, RYR1, CACNA1E | AR 902/4885CYP3A4 999/4885MAPT 3702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.