Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366630 | 0.90 | AR (0.69) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL16012292 | 0.89 | AR (0.67) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL1822971 | 0.87 | AR (0.73) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL5082108 | 0.86 | AR (1.00) | ARCYP3A4MAPTMAPK1ADORA3 | |
| SCHEMBL4358326 | 0.86 | AR (0.63) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL4361748 | 0.86 | AR (0.63) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL4362358 | 0.85 | AR (0.67) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL16012391 | 0.85 | KDM4E (0.62) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL7956418 | 0.84 | KDM4E (0.68) | ARCYP3A4MAPTMAPK1KDM4E | |
| SCHEMBL4366665 | 0.84 | AR (0.76) | ARCYP3A4MAPTMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166548-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | SANOFI (FR) | 2017-06-15 | — | — | US | disclosed |
| EP-2964623-B1 | SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2016-11-02 | — | — | EP | disclosed |
| US-9440941-B2 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | SANOFI (FR) | 2016-09-13 | — | — | US | disclosed |
| US-20160016928-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | SANOFI (FR) | 2016-01-21 | — | — | US | disclosed |
| EP-2964623-A1 | SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135674-A1 | SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2014-09-12 | — | — | WO | disclosed |
| US-7482340-B2 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | ORION CORPORATION (FI) | 2009-01-27 | — | — | US | disclosed |
| US-7425568-B2 | Compounds, which are potent inhibitors of Na+ /Ca2+ exchange mechanism and are useful in the treatment of arrhythmias | ORION CORPORATION (FI) | 2008-09-16 | — | — | US | disclosed |
| US-20060241147-A1 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | ORION CORPORATION (FI) | 2006-10-26 | — | — | US | disclosed |
| EP-1412343-B1 | COMPOUNDS, WHICH ARE POTENT INHIBITORS OF NA+/CA2+ EXCHANGE MECHANISM AND ARE USEFUL IN THE TREATMENT OF ARRHYTHMIAS | ORION CORP (FI) | 2006-08-30 | — | — | EP | disclosed |
| EP-1583759-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2005-10-12 | — | — | EP | disclosed |
| US-20040235905-A1 | Compounds, which are potent inhibitors of na+ / ca2+ exchange mechanism and are useful in the treatment of arrhythmias | ORION CORPORATION (FI) | 2004-11-25 | — | — | US | disclosed |
| WO-2004063191-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2004-07-29 | — | — | WO | disclosed |
| EP-1412343-A1 | NEW COMPOUNDS, WHICH ARE POTENT INHIBITORS OF NA+/CA2+ EXCHANGE MECHANISM AND ARE USEFUL IN THE TREATMENT OF ARRHYTHMIAS | ORION CORPORATION (FI) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003006452-A1 | NEW COMPOUNDS, WHICH ARE POTENT INHIBITORS OF NA+/CA2+ EXCHANGE MECHANISM AND ARE USEFUL IN THE TREATMENT OF ARRHYTHMIAS | ORION CORPORATION (FI) | 2003-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235905-A1 | Compounds, which are potent inhibitors of na+ / ca2+ exchange mechanism and are useful in the treatment of arrhythmias | CACNA1E, KCNN4, RYR2 | AR 965/4885CYP3A4 679/4885MAPT 4853/4885 |
| US-20160016928-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | RYR2, RYR1, CACNA1E | AR 912/4885CYP3A4 1023/4885MAPT 3715/4885 |
| US-20170166548-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | RYR2, RYR1, CACNA1E | AR 902/4885CYP3A4 999/4885MAPT 3702/4885 |
| US-20060241147-A1 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | SLC8B1, CACNA1A, MCU | AR 3262/4885CYP3A4 655/4885MAPT 2223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.