Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL337736 | 0.94 | TDP1 (0.70) | TDP1ALDH1A1KMT2AKEAP1FFAR1 | |
| Butane SCHEMBL27593871 | 0.91 | TDP1 (0.61) | TDP1ALDH1A1KMT2AKEAP1FFAR1 | |
| Benzylacetone SCHEMBL27902841 | 0.84 | ALDH1A1 (0.88) | TDP1ALDH1A1KMT2AKEAP1FFAR1 | |
| SCHEMBL7364196 | 0.82 | HDAC1 (0.64) | TDP1KMT2AKEAP1NPC1RAB9A | |
| SCHEMBL8375457 | 0.82 | KDM4E (0.55) | TDP1ALDH1A1KMT2AKDM4ENPC1 | |
| SCHEMBL466545 | 0.81 | TDP1 (0.63) | TDP1ALDH1A1KMT2AKEAP1FFAR1 | |
| Methyl 3-Phenylpropanoate SCHEMBL17748824 | 0.81 | TDP1 (0.63) | TDP1ALDH1A1KMT2AKEAP1FFAR1 | |
| SCHEMBL26927562 | 0.81 | MAPT (0.63) | TDP1KMT2ANPC1RAB9AHDAC2 | |
| Methyl 3-Phenylpropanoate SCHEMBL168711 | 0.80 | TDP1 (0.68) | TDP1ALDH1A1KMT2AKEAP1FFAR1 | |
| SCHEMBL8376797 | 0.80 | KDM4E (0.52) | TDP1KMT2AKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964212-A1 | CABAZITAXEL AND ITS USE FOR TREATING METASTATIC PROSTATE CANCERS | Aventis Pharma S.A. (FR) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135524-A1 | CABAZITAXEL AND ITS USE FOR TREATING METASTATIC PROSTATE CANCERS | AVENTIS PHARMA S.A. (FR) | 2014-09-12 | — | — | WO | disclosed |