SCHEMBL16014387

SCHEMBL16014387

COc1cc(C)cc(-c2c(O)ccc3ccccc23)c1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.49
STAT3 P40763 1/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
HSP90AA1 P07900 5/20 0.47
HSP90AB1 P08238 4/20 0.47
ALOX5 P09917 1/20 0.44
PPARG P37231 2/20 0.43
RAB9A P51151 2/20 0.43
NPC1 O15118 1/20 0.43
GAA P10253 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CETP P11597 1/20 0.42
ALDH1A1 P00352 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C19 P33261 1/20 0.41
HIF1A Q16665 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18241055 0.90 MAPT (0.58) MAPTMEN1KMT2AALOX5PPARG
SCHEMBL17811450 0.88 MAPT (0.51) MAPTMEN1KMT2AALOX5PPARG
SCHEMBL28079325 0.82 STAT3 (0.44) MAPTSTAT3MEN1KMT2AHSP90AA1
SCHEMBL19909611 0.81 MAPT (0.55) MAPTSTAT3MEN1KMT2AHSP90AA1
SCHEMBL21001939 0.80 MAPT (0.54) MAPTMEN1KMT2AHSP90AA1HSP90AB1
SCHEMBL16014403 0.79 MAPT (0.50) MAPTSTAT3MEN1KMT2AHSP90AA1
SCHEMBL19672933 0.78 SOS1 (0.41) MAPTSTAT3MEN1KMT2ARAB9A
SCHEMBL20752767 0.78 MAPT (0.41) MAPTMEN1KMT2AHSP90AA1HSP90AB1
SCHEMBL20308908 0.78 SOS1 (0.41) MAPTSTAT3MEN1KMT2ARAB9A
SCHEMBL17808711 0.78 HSP90AA1 (0.46) MAPTSTAT3MEN1KMT2AHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3029057-B1 BIS-PHOSPHITES WITH AN ASYMMETRIC BIARYL CENTRAL COMPONENT EVONIK DEGUSSA GMBH (DE) 2019-02-20 EP disclosed
EP-3031815-B1 TERPHENYL-2-OXY-PHOSPHITES AS LIGANDS IN HYDROFORMYLATION CATALYSTS EVONIK DEGUSSA GMBH (DE) 2019-02-20 EP disclosed
US-9982001-B2 Bisphosphites having an unsymmetric central biaryl unit EVONIK DEGUSSA GMBH (DE) 2018-05-29 US disclosed
US-9982001-B2 Bisphosphites having an unsymmetric central biaryl unit EVONIK DEGUSSA GMBH (DE) 2018-05-29 US disclosed
EP-2964812-B1 ELECTROCHEMICAL COUPLING OF A PHENOL TO A NAPHTHOL EVONIK DEGUSSA GMBH (DE) 2018-03-21 EP disclosed
EP-2964812-B1 ELECTROCHEMICAL COUPLING OF A PHENOL TO A NAPHTHOL EVONIK DEGUSSA GMBH (DE) 2018-03-21 EP disclosed
EP-3029050-B1 Bis-phosphites with a naphthyl-phenyl unit as fin component EVONIK DEGUSSA GMBH (DE) 2018-02-28 EP disclosed
EP-3101022-B1 MONOPHOSPHITES HAVING AN UNSYMMETRIC BIARYL UNIT EVONIK DEGUSSA GMBH (DE) 2018-02-28 EP disclosed
EP-3029052-B1 9-Anthrol-monophosphit Esters as Ligands for Hydroformylation Catalysts EVONIK DEGUSSA GMBH (DE) 2018-02-28 EP disclosed
US-9670585-B2 Electrochemical coupling of a phenol to a naphthol EVONIK DEGUSSA GMBH (DE) 2017-06-06 US disclosed
EP-3029051-A1 Bis-phosphites with a naphthyl-phenyl unit as fin component and a 2.3'-bisphenol unit as central component Evonik Degussa GmbH (DE) 2016-06-08 EP disclosed
EP-3029051-A1 Bis-phosphites with a naphthyl-phenyl unit as fin component and a 2.3'-bisphenol unit as central component Evonik Degussa GmbH (DE) 2016-06-08 EP disclosed
EP-3029055-A1 Monophosphites with asymmetric biaryl component Evonik Degussa GmbH (DE) 2016-06-08 EP disclosed
EP-3029047-A1 Terphenyl-2-oxy-phosphites as ligands in hydroformylation catalysts Evonik Degussa GmbH (DE) 2016-06-08 EP disclosed
US-20160017505-A1 ELECTROCHEMICAL COUPLING OF A PHENOL TO A NAPHTHOL EVONIK DEGUSSA GMBH (CH) 2016-01-21 US disclosed
US-20160017505-A1 ELECTROCHEMICAL COUPLING OF A PHENOL TO A NAPHTHOL EVONIK DEGUSSA GMBH (CH) 2016-01-21 US disclosed
US-20160017505-A1 ELECTROCHEMICAL COUPLING OF A PHENOL TO A NAPHTHOL EVONIK DEGUSSA GMBH (CH) 2016-01-21 US disclosed
EP-2964812-A1 ELECTROCHEMICAL COUPLING OF A PHENOL TO A NAPHTHOL Evonik Degussa GmbH (DE) 2016-01-13 EP disclosed
WO-2014135237-A1 ELECTROCHEMICAL COUPLING OF A PHENOL TO A NAPHTHOL EVONIK INDUSTRIES AG (DE) 2014-09-12 WO disclosed
WO-2014135237-A1 ELECTROCHEMICAL COUPLING OF A PHENOL TO A NAPHTHOL EVONIK INDUSTRIES AG (DE) 2014-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160017505-A1 ELECTROCHEMICAL COUPLING OF A PHENOL TO A NAPHTHOL NQO1, COMT, NQO2 MAPT 3180/4885STAT3 2615/4885MEN1 3672/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.