Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | KRAS | P01116 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19672933 | 1.00 | SOS1 (0.41) | SOS1EGFRKRASMAPTKMT2A | |
| SCHEMBL19672931 | 0.83 | RCE1 (0.38) | MAPTKMT2AMEN1STAT3 | |
| SCHEMBL20308912 | 0.83 | RCE1 (0.38) | MAPTKMT2AMEN1STAT3 | |
| SCHEMBL18241055 | 0.79 | MAPT (0.58) | MAPTKMT2AMEN1HIF1ARAB9A | |
| SCHEMBL19672981 | 0.78 | CA1 (0.39) | SOS1MAPTKMT2AMEN1STAT3 | |
| SCHEMBL19672979 | 0.78 | CA1 (0.39) | SOS1MAPTKMT2AMEN1STAT3 | |
| SCHEMBL16014387 | 0.78 | MAPT (0.49) | MAPTKMT2AMEN1HIF1ASTAT3 | |
| SCHEMBL17811450 | 0.77 | MAPT (0.51) | MAPTKMT2AMEN1HIF1ARAB9A | |
| SCHEMBL20308925 | 0.76 | TP53 (0.36) | SOS1KRASMAPTKMT2AMEN1 | |
| SCHEMBL20308929 | 0.76 | CCNE2 (0.33) | MAPTKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252033-B1 | TWO-STAGE SYNTHESIS OF N BIARYL COMPOUNDS | EVONIK DEGUSSA GMBH (DE) | 2018-06-27 | — | — | EP | disclosed |