Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 16/20 | 0.57 |
| ▸ | PDE4A | P27815 | 5/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508639 | 0.78 | PDE4D (0.69) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL187938 | 0.76 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL187090 | 0.72 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL187315 | 0.72 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4C | |
| Bicarbonate SCHEMBL301011 | 0.71 | PDE4A (0.96) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL187323 | 0.70 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4C | |
| Carbamic Acid SCHEMBL300981 | 0.70 | PDE4A (0.93) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL508869 | 0.69 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL300759 | 0.68 | PDE4A (0.83) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL300740 | 0.67 | PDE4A (0.82) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829190-B2 | Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases | LEO PHARMA A/S (DK) | 2014-09-09 | — | — | US | disclosed |