Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13451458 | 0.87 | — | — | |
| SCHEMBL8002686 | 0.75 | CETP (0.44) | SMN1; SMN2CYP3A4ALDH1A1LMNACETP | |
| SCHEMBL3903447 | 0.75 | DGAT1 (0.41) | SMN1; SMN2HDAC4KDM4EALDH1A1USP2 | |
| SCHEMBL15199091 | 0.75 | CYP2C9 (0.34) | LMNACYP1A2 | |
| SCHEMBL15199090 | 0.75 | CYP2C9 (0.34) | LMNACYP1A2 | |
| SCHEMBL30936120 | 0.74 | KDM4E (0.32) | KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL27934607 | 0.73 | CETP (0.43) | SMN1; SMN2CYP3A4ALDH1A1LMNACETP | |
| SCHEMBL19429478 | 0.73 | SMN1; SMN2 (0.40) | SMN1; SMN2CYP3A4ALDH1A1NPSR1USP2 | |
| SCHEMBL4133242 | 0.73 | CYP3A4 (0.40) | SMN1; SMN2CYP3A4KDM4EALDH1A1NPSR1 | |
| SCHEMBL7522834 | 0.73 | CYP3A4 (0.40) | SMN1; SMN2CYP3A4KDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |
| EP-3141252-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Inc. (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9345708-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-05-24 | — | — | US | disclosed |
| US-8829007-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-09 | — | — | US | disclosed |