Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CRACR2A | Q9BSW2 | 3/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887330 | 0.89 | CRACR2A (0.54) | POLBMAPTCRACR2AEPAS1STIM1 | |
| SCHEMBL16019794 | 0.86 | CRACR2A (0.43) | POLBMAPTCRACR2ASTIM1ORAI1 | |
| SCHEMBL16019790 | 0.86 | POLB (0.45) | POLBMAPTCRACR2AEPAS1STIM1 | |
| SCHEMBL16019796 | 0.84 | CRACR2A (0.43) | POLBMAPTCRACR2AEPAS1STIM1 | |
| SCHEMBL16019799 | 0.83 | STIM1 (0.43) | POLBMAPTCRACR2AEPAS1STIM1 | |
| SCHEMBL16017186 | 0.82 | STIM1 (0.42) | POLBMAPTCRACR2ASTIM1ORAI1 | |
| SCHEMBL16017189 | 0.82 | STIM1 (0.51) | POLBCRACR2ASTIM1ORAI1LMNA | |
| SCHEMBL16017209 | 0.81 | RAB9A (0.47) | POLBMAPTCRACR2ASTIM1ORAI1 | |
| SCHEMBL16017183 | 0.81 | CRACR2A (0.55) | MAPTCRACR2ASTIM1ORAI1KDM4E | |
| SCHEMBL16008936 | 0.81 | STIM1 (0.52) | POLBMAPTCRACR2ASTIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | POLB 4774/4885MAPT 1478/4885CRACR2A 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.