Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16019883 | 0.92 | HDAC6 (0.45) | HDAC6SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL16017402 | 0.90 | HDAC6 (0.47) | HDAC6SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL16017395 | 0.88 | SMN1; SMN2 (0.43) | HDAC6SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL16017397 | 0.88 | LMNA (0.46) | HDAC6SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL16017399 | 0.88 | SMN1; SMN2 (0.43) | HDAC6SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL16019884 | 0.88 | HDAC6 (0.45) | HDAC6SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL16017392 | 0.86 | ITGB1 (0.44) | HDAC6SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL16017405 | 0.83 | NPC1 (0.58) | HDAC6SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL16019825 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAHTTTRPA1GAA | |
| SCHEMBL14887629 | 0.81 | SNCA (0.39) | SMN1; SMN2LMNAHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | HDAC6 1662/4885SMN1; SMN2 854/4885LMNA 1306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.