Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16019779 | 0.90 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTPOLBHTT | |
| SCHEMBL16017243 | 0.89 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTPOLBHTT | |
| SCHEMBL16017250 | 0.87 | RAF1 (0.42) | ALDH1A1MAPTPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL16017176 | 0.84 | STIM1 (0.41) | ALDH1A1MAPTPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL29420773 | 0.84 | MAPT (0.52) | ALDH1A1MAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL16017420 | 0.84 | MAPT (0.52) | ALDH1A1MAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL16017227 | 0.82 | KDM4E (0.44) | ALDH1A1MAPTPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL16017189 | 0.82 | STIM1 (0.51) | ALDH1A1LMNAPOLBHTTRAB9A | |
| SCHEMBL16017419 | 0.81 | ALDH1A1 (0.50) | ALDH1A1POLBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL16017183 | 0.81 | CRACR2A (0.55) | ALDH1A1MAPTRAB9ASMN1; SMN2STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | ALDH1A1 4409/4885LMNA 1306/4885MAPT 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.