Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.39 |
| ▸ | IL2 | P60568 | 5/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16019811 | 0.91 | MAPT (0.38) | MAPTPOLBTDP1L3MBTL1STIM1 | |
| SCHEMBL16020536 | 0.89 | STIM1 (0.48) | MAPTPOLBTDP1L3MBTL1STIM1 | |
| SCHEMBL16017286 | 0.82 | SCN9A (0.38) | MAPTSTIM1ORAI1IL2SCN9A | |
| SCHEMBL16009312 | 0.82 | ALDH1A1 (0.46) | MAPTPOLBSTIM1ORAI1IL2 | |
| SCHEMBL16020538 | 0.82 | STIM1 (0.47) | MAPTPOLBTDP1L3MBTL1STIM1 | |
| SCHEMBL14885579 | 0.80 | STIM1 (0.47) | MAPTPOLBTDP1L3MBTL1STIM1 | |
| SCHEMBL14881331 | 0.79 | ALDH1A1 (0.45) | MAPTPOLBL3MBTL1STIM1ORAI1 | |
| SCHEMBL14881324 | 0.78 | HTT (0.52) | MAPTTDP1STIM1ORAI1ALDH1A1 | |
| SCHEMBL16017216 | 0.76 | STIM1 (0.40) | MAPTL3MBTL1STIM1ORAI1IL2 | |
| SCHEMBL16017194 | 0.76 | STIM1 (0.40) | L3MBTL1STIM1ORAI1IL2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | MAPT 1478/4885POLB 4774/4885TDP1 3096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.