Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16019804 | 0.93 | HDAC3 (0.43) | KCNQ3KCNQ2KCNE1KCNQ1BUB1 | |
| SCHEMBL14887772 | 0.90 | SCN8A (0.40) | KCNQ3KCNQ2KCNE1KCNQ1GRM4 | |
| SCHEMBL16019838 | 0.89 | GRM4 (0.44) | BUB1CRACR2AGRM4HDAC3HDAC1 | |
| SCHEMBL14887752 | 0.89 | RAB9A (0.47) | CRACR2AGRM4STIM1ORAI1HTT | |
| SCHEMBL14887759 | 0.88 | KCNQ3 (0.42) | KCNQ3KCNQ2KCNE1KCNQ1NTRK1 | |
| SCHEMBL16017306 | 0.87 | HTT (0.46) | FLT1LMNAHTTSMN1; SMN2SCN8A | |
| SCHEMBL14887598 | 0.86 | GRM4 (0.41) | KCNQ3KCNQ2KCNE1KCNQ1BUB1 | |
| SCHEMBL16019800 | 0.83 | HDAC3 (0.41) | GRM4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL14887761 | 0.82 | HDAC3 (0.43) | KCNQ3KCNQ2KCNE1KCNQ1HDAC3 | |
| SCHEMBL16017302 | 0.82 | RAB9A (0.47) | CRACR2AGRM4STIM1ORAI1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | KCNQ3 282/4885KCNQ2 173/4885KCNE1 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.