Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16301302 | 0.85 | DRD1 (0.49) | ALDH1A1MAPTCOMTDRD1PDE3B | |
| SCHEMBL13036097 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPTCOMTDRD1PDE3B | |
| SCHEMBL16020167 | 0.82 | ALDH1A1 (0.58) | ALDH1A1MAPTCOMTDRD1PDE3B | |
| SCHEMBL24893262 | 0.82 | ALDH1A1 (0.43) | ESRRAALDH1A1MAPTCOMTDRD1 | |
| SCHEMBL13144356 | 0.82 | MAPT (0.50) | ESRRAALDH1A1MAPTCOMTATM | |
| SCHEMBL15248968 | 0.80 | HTR2A (0.53) | ALDH1A1MAPTBRD4SCN9AKDM4E | |
| SCHEMBL16900307 | 0.80 | ALDH1A1 (0.41) | ALDH1A1MAPTCOMTDRD1PDE3B | |
| SCHEMBL9911401 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MAPTCOMTDRD1PDE3B | |
| SCHEMBL14708004 | 0.78 | CYP1A2 (0.54) | ALDH1A1MAPTSCN9ACYP1A2METAP2 | |
| SCHEMBL16545859 | 0.77 | FLT1 (0.45) | ALDH1A1MAPTCOMTDRD1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079902-B2 | Heteroaryl sodium channel inhibitors | AMGEN INC. (US) | 2015-07-14 | — | — | US | disclosed |
| US-20140256707-A1 | Heteroaryl Sodium Channel Inhibitors | AMGEN INC. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256707-A1 | Heteroaryl Sodium Channel Inhibitors | SCN1A, SCN5A, SCN1B | ESRRA 4811/4885ALDH1A1 1377/4885MAPT 3233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.