SCHEMBL16020658

SCHEMBL16020658

Nc1nc2c(ncn2C[C@@H](CF)OCP(=O)(O)O)c(=O)[nH]1

nearest known ligand 0.81

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 18/20 0.81
PNP P00491 1/20 0.57
MEN1 O00255 1/20 0.57
ALDH1A1 P00352 1/20 0.57
LMNA P02545 1/20 0.57
CYP3A4 P08684 1/20 0.57
NFKB1 P19838 1/20 0.57
BLM P54132 1/20 0.57
VCP P55072 1/20 0.57
KMT2A Q03164 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
HIF1A Q16665 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3856994 1.00 HPRT1 (0.81) HPRT1PNPMEN1ALDH1A1LMNA
SCHEMBL9189420 1.00 HPRT1 (0.81) HPRT1PNPMEN1ALDH1A1LMNA
SCHEMBL173060 0.91 HPRT1 (0.81) HPRT1PNPMEN1ALDH1A1LMNA
SCHEMBL9175736 0.91 HPRT1 (0.81) HPRT1PNPMEN1ALDH1A1LMNA
SCHEMBL84257 0.91 HPRT1 (0.81) HPRT1PNPMEN1ALDH1A1LMNA
SCHEMBL16057472 0.89 HPRT1 (0.68) HPRT1
SCHEMBL17194159 0.88 HPRT1 (0.70) HPRT1PNPMEN1ALDH1A1LMNA
SCHEMBL14669070 0.88 HPRT1 (0.71) HPRT1MEN1ALDH1A1LMNACYP3A4
SCHEMBL14669071 0.88 HPRT1 (0.71) HPRT1MEN1ALDH1A1LMNACYP3A4
SCHEMBL14669187 0.88 HPRT1 (0.71) HPRT1MEN1ALDH1A1LMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12397058-B2 Metabolically stable prodrugs TSRL, INC. (US) 2025-08-26 US disclosed
EP-3401320-B1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS FOR USE IN TREATING HUMAN PAPILLOMA VIRUS, CERVICAL INTRAEPITHELIAL NEOPLASIA, ANAL INTRAEPITHELIAL NEOPLASIA, OR VULVAR INTRAEPITHELIAL NEOPLASIA UNIV CALIFORNIA (US) 2020-05-13 EP disclosed
US-10449207-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-10-22 US disclosed
EP-3515923-A1 PRODRUGS OF FLUORINATED ACYCLIC NUCLEOSIDE PHOSPHONATES Katholieke Universiteit Leuven (BE) 2019-07-31 EP disclosed
US-20180360859-A1 Acyclic Nucleoside Phosphonate Diesters NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-12-20 US disclosed
EP-3401320-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS FOR USE IN TREATING HUMAN PAPILLOMA VIRUS, CERVICAL INTRAEPITHELIAL NEOPLASIA, ANAL INTRAEPITHELIAL NEOPLASIA, OR VULVAR INTRAEPITHELIAL NEOPLASIA The Regents of the University of California (US) 2018-11-14 EP disclosed
US-10076533-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-09-18 US disclosed
US-10076532-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-09-18 US disclosed
EP-2970346-B1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS UNIV CALIFORNIA (US) 2018-08-08 EP disclosed
WO-2018055071-A1 PRODRUGS OF FLUORINATED ACYCLIC NUCLEOSIDE PHOSPHONATES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2018-03-29 WO disclosed
US-9775852-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-10-03 US disclosed
US-20170002033-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-01-05 US disclosed
US-9387217-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-07-12 US disclosed
US-20160015726-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2016-01-21 US disclosed
EP-2970346-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS The Regents of the University of California (US) 2016-01-20 EP disclosed
US-9156867-B2 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-10-13 US disclosed
US-20140364397-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION 2014-12-11 US disclosed
WO-2014143643-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) 2014-09-18 WO disclosed
US-20140275532-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) 2014-09-18 US disclosed
US-8835630-B1 Acyclic nucleoside phosphonate diesters THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) 2014-09-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160015726-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS NTPCR, PNP, TYMP HPRT1 57/4885PNP 2/4885MEN1 2016/4885
US-20180360859-A1 Acyclic Nucleoside Phosphonate Diesters NTPCR, PNP, TYMP HPRT1 57/4885PNP 2/4885MEN1 2016/4885
US-20170002033-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS NTPCR, PNP, TYMP HPRT1 57/4885PNP 2/4885MEN1 2016/4885
US-10449207-B2 Acyclic nucleoside phosphonate diesters NTPCR, PNP, TYMP HPRT1 57/4885PNP 2/4885MEN1 2016/4885
US-12397058-B2 Metabolically stable prodrugs CES1, CES2, CYP2S1 HPRT1 387/4885PNP 81/4885MEN1 1968/4885
US-20140275532-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS NTPCR, PNP, TYMP HPRT1 57/4885PNP 2/4885MEN1 2016/4885
US-10076532-B2 Acyclic nucleoside phosphonate diesters NTPCR, PNP, TYMP HPRT1 57/4885PNP 2/4885MEN1 2016/4885
US-10076533-B2 Acyclic nucleoside phosphonate diesters NTPCR, PNP, TYMP HPRT1 57/4885PNP 2/4885MEN1 2016/4885
US-20140364397-A1 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS NTPCR, PNP, TYMP HPRT1 57/4885PNP 2/4885MEN1 2016/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.