Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16062577 | 1.00 | MAPT (0.40) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL16948497 | 0.98 | KMT2A (0.39) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL10182417 | 0.91 | KMT2A (0.41) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL12752017 | 0.91 | KMT2A (0.41) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL15773712 | 0.91 | KMT2A (0.41) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL15586735 | 0.91 | KMT2A (0.41) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL15069645 | 0.91 | KDM2B (0.34) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL14705324 | 0.83 | ALDH1A1 (0.34) | KMT2ANPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL15804517 | 0.83 | ALDH1A1 (0.34) | KMT2ANPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL883147 | 0.83 | KMT2A (0.41) | MAPTKMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835456-B1 | NS5A inhibitors useful for treating HCV | ACHILLION PHARMACEUTICALS, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835456-B1 | NS5A inhibitors useful for treating HCV | ACHILLION PHARMACEUTICALS, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835456-B1 | NS5A inhibitors useful for treating HCV | ACHILLION PHARMACEUTICALS, INC. (US) | 2014-09-16 | — | — | US | disclosed |