Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419118 | 0.86 | ALDH1A1 (0.41) | KDM4EMAPTL3MBTL1GAAHSP90AA1 | |
| SCHEMBL12185616 | 0.85 | ALDH1A1 (0.40) | KDM4EMAPTL3MBTL1GAAHSP90AA1 | |
| SCHEMBL421083 | 0.83 | HSP90AA1 (0.51) | KDM4EMAPTL3MBTL1GAAHSP90AA1 | |
| SCHEMBL15026309 | 0.82 | KDM4E (0.47) | KDM4EMAPTL3MBTL1GAAHSP90AA1 | |
| SCHEMBL15042880 | 0.79 | ALDH1A1 (0.40) | KDM4EMAPTL3MBTL1GAAHSP90AA1 | |
| SCHEMBL8930478 | 0.77 | HSP90AA1 (0.76) | KDM4EMAPTL3MBTL1GAAHSP90AA1 | |
| SCHEMBL12637703 | 0.77 | HSP90AA1 (0.40) | KDM4EMAPTGAAHSP90AA1HSP90AB1 | |
| SCHEMBL8930527 | 0.76 | HSP90AA1 (0.59) | KDM4EMAPTL3MBTL1GAAHSP90AA1 | |
| SCHEMBL12066695 | 0.76 | HSP90AA1 (0.46) | KDM4EMAPTL3MBTL1GAAHSP90AA1 | |
| SCHEMBL8930932 | 0.76 | HSP90AA1 (0.73) | KDM4EMAPTL3MBTL1GAAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256680-A1 | COMBINATION THERAPY OF HSP90 INHIBITORS WITH BRAF INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256680-A1 | COMBINATION THERAPY OF HSP90 INHIBITORS WITH BRAF INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256680-A1 | COMBINATION THERAPY OF HSP90 INHIBITORS WITH BRAF INHIBITORS | BRAF, HSP90AB1, HSP90AA1 | KDM4E 3343/4885MAPT 20/4885L3MBTL1 4195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.