Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16012496 | 0.89 | MAPK6 (0.53) | MAPK6GSK3AGSK3BF10MAPK8 | |
| SCHEMBL17435396 | 0.88 | MAPK6 (0.46) | MAPK6GSK3AGSK3BAURKAF10 | |
| SCHEMBL18830594 | 0.88 | MAPK6 (0.45) | MAPK6GSK3AGSK3BAURKAF10 | |
| SCHEMBL18830595 | 0.87 | GSK3A (0.44) | MAPK6GSK3AGSK3BAURKAF10 | |
| Carbamic Acid SCHEMBL18813085 | 0.86 | MAPK6 (0.46) | MAPK6GSK3AGSK3BAURKAF10 | |
| SCHEMBL16013096 | 0.78 | MAPK6 (0.56) | MAPK6GSK3AGSK3BMAPK8MAPK9 | |
| SCHEMBL17435312 | 0.77 | MAPK6 (0.49) | MAPK6GSK3AGSK3BMAPK8MAPK9 | |
| SCHEMBL18830192 | 0.76 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL18830615 | 0.76 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16022138 | 0.76 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014135244-A1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2014-09-12 | — | — | WO | disclosed |