Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830595 | 0.95 | GSK3A (0.44) | MAPK6GSK3AGSK3BPTGS2F10 | |
| SCHEMBL16012496 | 0.90 | MAPK6 (0.53) | MAPK6GSK3AGSK3BF10JAK2 | |
| SCHEMBL17435396 | 0.89 | MAPK6 (0.46) | MAPK6GSK3AGSK3BF10AURKA | |
| Carbamic Acid SCHEMBL18813028 | 0.88 | MAPK6 (0.49) | MAPK6GSK3AGSK3BSYKMAPK8 | |
| SCHEMBL16022079 | 0.86 | MAPK6 (0.43) | MAPK6GSK3AGSK3BPTGS2F10 | |
| SCHEMBL18830594 | 0.86 | MAPK6 (0.45) | MAPK6GSK3AGSK3BPTGS2F10 | |
| SCHEMBL18830612 | 0.82 | GSK3A (0.48) | MAPK6GSK3AGSK3BSYKCDK2 | |
| Carbamic Acid SCHEMBL18813140 | 0.79 | MAPK6 (0.63) | MAPK6GSK3AGSK3BAURKACDK2 | |
| SCHEMBL16013096 | 0.78 | MAPK6 (0.56) | MAPK6GSK3AGSK3BSYKCCNE1 | |
| Carbamic Acid SCHEMBL18813340 | 0.77 | MAPK6 (0.54) | MAPK6GSK3AGSK3BAURKASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | claimed |