Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.60 |
| ▸ | TDO2 | P48775 | 8/20 | 0.60 |
| ▸ | EED | O75530 | 6/20 | 0.58 |
| ▸ | SUZ12 | Q15022 | 6/20 | 0.58 |
| ▸ | EZH2 | Q15910 | 6/20 | 0.58 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.58 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.55 |
| ▸ | CES2 | O00748 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CES1 | P23141 | 2/20 | 0.55 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.55 |
| ▸ | NSD1 | Q96L73 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16023775 | 0.90 | IDO1 (0.57) | IDO1TDO2EEDSUZ12EZH2 | |
| SCHEMBL16023774 | 0.81 | EED (0.66) | IDO1TDO2EEDSUZ12EZH2 | |
| SCHEMBL4114682 | 0.79 | EED (0.56) | IDO1TDO2EEDSUZ12EZH2 | |
| SCHEMBL16421134 | 0.79 | EED (0.56) | IDO1TDO2EEDSUZ12EZH2 | |
| SCHEMBL16023776 | 0.75 | EED (0.65) | IDO1TDO2EEDSUZ12EZH2 | |
| SCHEMBL30923422 | 0.75 | IDO1 (1.00) | IDO1TDO2EEDSUZ12EZH2 | |
| SCHEMBL30978884 | 0.74 | IDO1 (0.61) | IDO1TDO2EEDSUZ12EZH2 | |
| SCHEMBL14417695 | 0.74 | EED (1.00) | IDO1TDO2EEDSUZ12EZH2 | |
| SCHEMBL16152287 | 0.74 | EED (1.00) | IDO1TDO2EEDSUZ12EZH2 | |
| SCHEMBL14417701 | 0.74 | EED (1.00) | IDO1TDO2EEDSUZ12EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160022625-A1 | TASHINONES AND THEIR DERIVATIVES: NOVEL EXCELLENT DRUGS FOR ALZHEIMER DISEASE | THE UNIVERSITY OF AKRON | 2016-01-28 | — | — | US | disclosed |
| US-20160022625-A1 | TASHINONES AND THEIR DERIVATIVES: NOVEL EXCELLENT DRUGS FOR ALZHEIMER DISEASE | THE UNIVERSITY OF AKRON | 2016-01-28 | — | — | US | disclosed |
| WO-2014138357-A1 | NOVEL TASHINONE DRUGS FOR ALZHEIMER DISEASE | THE UNIVERSITY OF AKRON (US) | 2014-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022625-A1 | TASHINONES AND THEIR DERIVATIVES: NOVEL EXCELLENT DRUGS FOR ALZHEIMER DISEASE | APP, HTT, PSEN1 | IDO1 3609/4885TDO2 2457/4885EED 4772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.