Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 6/20 | 0.56 |
| ▸ | SUZ12 | Q15022 | 6/20 | 0.56 |
| ▸ | EZH2 | Q15910 | 6/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.56 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.56 |
| ▸ | CES2 | O00748 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CES1 | P23141 | 2/20 | 0.56 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.56 |
| ▸ | NSD1 | Q96L73 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
| ▸ | TERT | O14746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16421134 | 1.00 | EED (0.56) | EEDSUZ12EZH2HIF1AEPAS1 | |
| SCHEMBL13639801 | 0.90 | EED (0.46) | EEDSUZ12EZH2HIF1AEPAS1 | |
| SCHEMBL16023779 | 0.79 | IDO1 (0.60) | EEDSUZ12EZH2HIF1AEPAS1 | |
| SCHEMBL16152317 | 0.77 | EED (0.62) | EEDSUZ12EZH2HIF1AEPAS1 | |
| SCHEMBL16023774 | 0.77 | EED (0.66) | EEDSUZ12EZH2HIF1AEPAS1 | |
| SCHEMBL8199773 | 0.76 | MEN1 (0.63) | EEDSUZ12EZH2HIF1AEPAS1 | |
| SCHEMBL16421122 | 0.76 | MEN1 (0.63) | EEDSUZ12EZH2HIF1AEPAS1 | |
| SCHEMBL16023775 | 0.76 | IDO1 (0.57) | EEDSUZ12EZH2HIF1AEPAS1 | |
| SCHEMBL14417727 | 0.75 | EED (0.60) | EEDSUZ12EZH2HIF1AEPAS1 | |
| SCHEMBL30978884 | 0.72 | IDO1 (0.61) | EEDSUZ12EZH2HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160022625-A1 | TASHINONES AND THEIR DERIVATIVES: NOVEL EXCELLENT DRUGS FOR ALZHEIMER DISEASE | THE UNIVERSITY OF AKRON | 2016-01-28 | — | — | US | disclosed |
| US-20160022625-A1 | TASHINONES AND THEIR DERIVATIVES: NOVEL EXCELLENT DRUGS FOR ALZHEIMER DISEASE | THE UNIVERSITY OF AKRON | 2016-01-28 | — | — | US | disclosed |
| EP-2829880-A1 | Method for identifying modulators of BCRP/ABCG2-mediated ATP release and use of said modulators for treating diseases | Energeia Biosciences (NL) | 2015-01-28 | — | — | EP | disclosed |
| WO-2014138357-A1 | NOVEL TASHINONE DRUGS FOR ALZHEIMER DISEASE | THE UNIVERSITY OF AKRON (US) | 2014-09-12 | — | — | WO | disclosed |
| US-8513227-B2 | Inhibition of inflammatory cytokine production with tanshinones | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-08-20 | — | — | US | disclosed |
| EP-1981489-B1 | INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION WITH TANSHINONES | THE FEINSTEIN INST MEDICAL RES (US) | 2013-05-01 | — | — | EP | disclosed |
| US-20090221542-A1 | Inhibition of Inflammatory Cytokine Production With Tanshinones | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2009-09-03 | — | — | US | disclosed |
| EP-1981489-A2 | INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION WITH TANSHINONES | The Feinstein Institute for Medical Research (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084419-A2 | INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION WITH TANSHINONES | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022625-A1 | TASHINONES AND THEIR DERIVATIVES: NOVEL EXCELLENT DRUGS FOR ALZHEIMER DISEASE | APP, HTT, PSEN1 | EED 4772/4885SUZ12 4771/4885EZH2 4860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.