Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 12/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16014462 | 0.92 | TNIK (0.54) | TNIKROCK2ROCK1 | |
| SCHEMBL16014355 | 0.80 | TNIK (0.58) | TNIKROCK2ROCK1 | |
| SCHEMBL17957873 | 0.77 | ROCK2 (0.60) | TNIKROCK2ROCK1 | |
| SCHEMBL17368202 | 0.76 | ROCK2 (0.45) | TNIKROCK2ROCK1 | |
| SCHEMBL17957628 | 0.75 | TNIK (0.56) | TNIKROCK2ROCK1 | |
| SCHEMBL1726059 | 0.74 | GAA (0.46) | TNIKROCK2ROCK1 | |
| SCHEMBL8365726 | 0.72 | GAA (0.50) | TNIKROCK2ROCK1 | |
| SCHEMBL17957654 | 0.71 | ROCK2 (0.53) | TNIKROCK2ROCK1 | |
| SCHEMBL19929676 | 0.70 | ROCK2 (0.72) | TNIKROCK2ROCK1 | |
| SCHEMBL28882904 | 0.69 | ROCK2 (0.71) | TNIKROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964642-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2017-11-15 | — | — | EP | disclosed |
| WO-2014135474-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2014-09-12 | — | — | WO | disclosed |