Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 5/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1602892 | 0.78 | HDAC3 (0.47) | FYNHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL3489559 | 0.75 | HDAC3 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1602686 | 0.71 | HDAC3 (0.46) | FYNHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL18613508 | 0.70 | FYN (1.00) | FYN | |
| SCHEMBL6076416 | 0.69 | MAPK14 (0.51) | MAPK14CSNK1DMAPK13CSNK1EMAPK12 | |
| SCHEMBL27637349 | 0.69 | NR3C2 (0.52) | MEN1KMT2A | |
| SCHEMBL1601973 | 0.68 | HDAC6 (0.47) | FYNHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL17259238 | 0.67 | HDAC6 (0.45) | FYNHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL3489229 | 0.67 | HDAC6 (0.53) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3489166 | 0.66 | MAPK14 (0.42) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919488-B2 | Therapeutic compounds | PFIZER INC. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7919488-B2 | Therapeutic compounds | PFIZER INC. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7919488-B2 | Therapeutic compounds | PFIZER INC. (US) | 2011-04-05 | — | — | US | disclosed |
| CN-101511812-A | Pyrazole derivatives as cytochrome P450 inhibitors | PFIZER PROD INC (US) | 2009-08-19 | — | — | CN | disclosed |
| EP-2046774-A1 | PYRAZOLE DERIVATIVES AS CYTOCHROME P450 INHIBITORS | Pfizer Products Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| US-20080021011-A1 | THERAPEUTIC COMPOUNDS | PFIZER INC | 2008-01-24 | — | — | US | disclosed |
| US-20080021011-A1 | THERAPEUTIC COMPOUNDS | PFIZER INC | 2008-01-24 | — | — | US | disclosed |
| US-20080021011-A1 | THERAPEUTIC COMPOUNDS | PFIZER INC | 2008-01-24 | — | — | US | disclosed |
| WO-2008004096-A1 | PYRAZOLE DERIVATIVES AS CYTOCHROME P450 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008004096-A1 | PYRAZOLE DERIVATIVES AS CYTOCHROME P450 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021011-A1 | THERAPEUTIC COMPOUNDS | SLC10A1, PCSK9, CFTR | FYN 1864/4885HDAC6 32/4885HDAC3 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.