Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3489729 | 0.96 | HDAC6 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3489559 | 0.91 | HDAC3 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3488202 | 0.85 | HDAC3 (0.49) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3488373 | 0.82 | HDAC3 (0.46) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3488136 | 0.80 | HDAC3 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3489904 | 0.79 | HDAC3 (0.49) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3488974 | 0.78 | HDAC6 (0.71) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3488100 | 0.78 | TP53 (0.49) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3489652 | 0.78 | HDAC6 (0.56) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3489568 | 0.78 | HDAC3 (0.48) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | NR3C2, MC2R, NR3C1 | HDAC6 1944/4885HDAC3 1381/4885HDAC4 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.