Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16039283 | 0.87 | KMT2A (0.51) | KMT2AMAPTSMN1; SMN2MEN1ESR1 | |
| SCHEMBL16038480 | 0.86 | KMT2A (0.53) | KMT2AMAPTSMN1; SMN2MEN1ESR1 | |
| SCHEMBL8207859 | 0.85 | MRGPRX4 (0.55) | KMT2AMAPTSMN1; SMN2MEN1TTR | |
| SCHEMBL9743098 | 0.83 | ESR1 (0.66) | KMT2AMAPTSMN1; SMN2MEN1ESR1 | |
| SCHEMBL8204812 | 0.82 | KMT2A (0.54) | KMT2AMAPTSMN1; SMN2MEN1LMNA | |
| SCHEMBL27727216 | 0.82 | CYP1A2 (0.54) | KMT2AMAPTSMN1; SMN2MEN1ESR1 | |
| SCHEMBL28337798 | 0.81 | KMT2A (0.60) | KMT2AMAPTMEN1TTRLMNA | |
| SCHEMBL5693506 | 0.80 | TTR (0.53) | MAPTHSD17B10TTRLMNANR1I2 | |
| SCHEMBL28663041 | 0.80 | KMT2A (0.52) | KMT2AMAPTSMN1; SMN2MEN1ESR1 | |
| SCHEMBL11089698 | 0.79 | KMT2A (0.60) | KMT2AMAPTSMN1; SMN2MEN1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014140220-A1 | PROCESS FOR THE PREPARATION OF (2,3-DIHYDRO-BENZO[B][1,4]DIOXIN-2-YL) METHANOL DERIVATIVES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014140220-A1 | PROCESS FOR THE PREPARATION OF (2,3-DIHYDRO-BENZO[B][1,4]DIOXIN-2-YL) METHANOL DERIVATIVES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2014-09-18 | — | — | WO | disclosed |
| US-20140275576-A1 | PROCESS FOR THE PREPARATION OF (2,3-DIHYDRO-BENZO[B][1,4]DIOXIN-2-YL) METHANOL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-18 | — | — | US | disclosed |
| US-20140275576-A1 | PROCESS FOR THE PREPARATION OF (2,3-DIHYDRO-BENZO[B][1,4]DIOXIN-2-YL) METHANOL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-18 | — | — | US | disclosed |
| US-20140275576-A1 | PROCESS FOR THE PREPARATION OF (2,3-DIHYDRO-BENZO[B][1,4]DIOXIN-2-YL) METHANOL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275576-A1 | PROCESS FOR THE PREPARATION OF (2,3-DIHYDRO-BENZO[B][1,4]DIOXIN-2-YL) METHANOL DERIVATIVES | CYP1B1, CYP1A1, CYP4B1 | KMT2A 1117/4885MAPT 3962/4885SMN1; SMN2 1767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.