Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | CENPE | Q02224 | 6/20 | 0.33 |
| ▸ | PDE4A | P27815 | 5/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247556 | 0.83 | TRPM8 (0.43) | TRPM8CENPEPDE4APDE4BPDE4C | |
| SCHEMBL16038244 | 0.79 | TRPM8 (0.46) | TRPM8CENPEPDE4APDE4BPDE4C | |
| SCHEMBL16039908 | 0.78 | HCRTR1 (0.34) | TRPM8HCRTR1HCRTR2CLK1DYRK1A | |
| SCHEMBL2012809 | 0.73 | TRPM8 (0.48) | TRPM8CENPEPDE4APDE4BPDE4C | |
| SCHEMBL2017114 | 0.70 | KDM4E (0.41) | TRPM8CLK1CLK2DYRK1AKDM4E | |
| SCHEMBL16039095 | 0.70 | TRPM8 (0.47) | TRPM8PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1325425 | 0.69 | GRIN2B (0.36) | TRPM8GRIN2B | |
| SCHEMBL2036111 | 0.67 | TRPM8 (0.49) | TRPM8PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2015181 | 0.65 | TRPM8 (0.47) | TRPM8PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2041772 | 0.65 | GRM5 (0.41) | TRPM8CENPEPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275127-A1 | SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275127-A1 | SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS | PIK3CA, PIK3CD, PIK3R5 | TRPM8 4728/4885CENPE 4486/4885PDE4A 1543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.