Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | NTSR2 | O95665 | 2/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 6/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16040015 | 1.00 | ACE (0.45) | ACEITGB3ITGA2BNTSR2NTSR1 | |
| SCHEMBL14486494 | 1.00 | ACE (0.45) | ACEITGB3ITGA2BNTSR2NTSR1 | |
| SCHEMBL14486485 | 1.00 | ACE (0.45) | ACEITGB3ITGA2BNTSR2NTSR1 | |
| SCHEMBL14485988 | 0.96 | ACE (0.48) | ACEITGB3ITGA2BNTSR2NTSR1 | |
| SCHEMBL14485983 | 0.96 | ACE (0.48) | ACEITGB3ITGA2BNTSR2NTSR1 | |
| SCHEMBL29588517 | 0.87 | ACE (0.52) | ACEREN | |
| SCHEMBL29802042 | 0.87 | ACE (0.48) | ACEREN | |
| SCHEMBL29801692 | 0.86 | ACE (0.48) | ACEREN | |
| SCHEMBL29607893 | 0.85 | KDM1A (0.48) | ACEREN | |
| SCHEMBL29801844 | 0.85 | ACE (0.47) | ACEREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11795214-B2 | Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains | GENMAB A/S (DK) | 2023-10-24 | — | — | US | disclosed |
| US-20200131253-A1 | MODULATION OF COMPLEMENT-DEPENDENT CYTOTOXICITY THROUGH MODIFICATIONS OF THE C-TERMINUS OF ANTIBODY HEAVY CHAINS | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2020-04-30 | — | — | US | disclosed |
| US-10323081-B2 | Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains | GENMAG A/S (DK) | 2019-06-18 | — | — | US | disclosed |
| EP-2729496-B1 | MODULATION OF COMPLEMENT-DEPENDENT CYTOTOXICITY THROUGH MODIFICATIONS OF THE C-TERMINUS OF ANTIBODY HEAVY CHAINS | GENMAB AS (DK) | 2017-09-13 | — | — | EP | disclosed |
| US-20140271623-A1 | MODULATION OF COMPLEMENT-DEPENDENT CYTOTOXICITY THROUGH MODIFICATIONS OF THE C-TERMINUS OF ANTIBODY HEAVY CHAINS | GENMAB A/S (DK) | 2014-09-18 | — | — | US | disclosed |