Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | CDC7 | O00311 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | EPRS1 | P07814 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16042251 | 0.85 | BRD4 (0.71) | BRD4CDC7 | |
| SCHEMBL2215320 | 0.84 | BRD4 (0.75) | BRD4CDC7NOTUMDHODHKDM4E | |
| SCHEMBL2215748 | 0.83 | MAPK14 (0.58) | BRD4CDC7NOTUMMAPK14MEN1 | |
| SCHEMBL16045678 | 0.83 | BRD4 (0.55) | BRD4CDC7NOTUMCYP1A2KMT2A | |
| SCHEMBL16041651 | 0.80 | PDE3B (0.60) | BRD4RXFP1MEN1CYP1A2CYP3A4 | |
| SCHEMBL30463801 | 0.80 | MCL1 (0.54) | BRD4CDC7NOTUMMAPK14MEN1 | |
| SCHEMBL16042550 | 0.78 | CDC7 (0.51) | BRD4CDC7MEN1CYP3A4KMT2A | |
| SCHEMBL28689724 | 0.76 | BRD4 (0.48) | BRD4CDC7RXFP1NOTUMMEN1 | |
| SCHEMBL16042212 | 0.74 | BRD4 (0.52) | BRD4NOTUMKMT2AMYC | |
| SCHEMBL4767248 | 0.74 | CDC7 (0.78) | CDC7MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970193-B1 | PYRROLE AMIDE INHIBITORS | ABBVIE INC (US) | 2018-07-25 | — | — | EP | disclosed |
| US-9493411-B2 | Pyrrole-3-carboxamide bromodomain inhibitors | ABBVIE INC. (US) | 2016-11-15 | — | — | US | disclosed |
| EP-2970193-A1 | PYRROLE AMIDE INHIBITORS | AbbVie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014165127-A1 | PYRROLE AMIDE INHIBITORS | ABBVIE INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| US-20140275079-A1 | PYRROLE AMIDE INHIBITORS | ABBVIE INC. | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275079-A1 | PYRROLE AMIDE INHIBITORS | HDAC10, ARG1, CDK20 | BRD4 835/4885CDC7 2007/4885RXFP1 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.