Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 19/20 | 0.57 |
| ▸ | FASN | P49327 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16049747 | 0.88 | PKLR (0.55) | PKLR | |
| SCHEMBL16049777 | 0.88 | PKLR (0.57) | PKLRFASN | |
| SCHEMBL16050149 | 0.85 | PKLR (0.59) | PKLRFASN | |
| SCHEMBL16049593 | 0.85 | PKLR (0.52) | PKLR | |
| SCHEMBL16049678 | 0.84 | PKLR (0.53) | PKLRFASN | |
| SCHEMBL30517909 | 0.77 | PKLR (0.57) | PKLRFASN | |
| SCHEMBL28023821 | 0.77 | PKLR (0.59) | PKLR | |
| SCHEMBL30497037 | 0.75 | CA12 (0.56) | — | |
| SCHEMBL31726892 | 0.73 | PKLR (0.55) | PKLR | |
| SCHEMBL16083859 | 0.73 | PKLR (1.00) | PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | Agios Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014139144-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014139325-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |