PKLR — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1710566	1.00	20/20
SCHEMBL1710676	1.00	20/20
SCHEMBL1711005	1.00	20/20
SCHEMBL1711253	1.00	20/20
Alizarin Red (SCHEMBL728494)	1.00	13/20
SCHEMBL387223	0.51	13/20
SCHEMBL1710857	1.00	12/20
Alizarin Red (SCHEMBL1203855)	0.73	12/20
Alizarin Red (SCHEMBL433811)	0.71	12/20
Alizarin Red (SCHEMBL728495)	0.71	12/20
SCHEMBL1506814	0.71	12/20
SCHEMBL1506809	0.67	12/20
SCHEMBL1710943	0.79	11/20
SCHEMBL1711004	0.83	10/20
SCHEMBL419737	0.51	9/20
SCHEMBL1710881	1.00	8/20
SCHEMBL1710921	0.73	8/20
SCHEMBL1711136	0.70	8/20
SCHEMBL1711139	0.65	8/20
SCHEMBL436684	0.55	8/20

Clinical trials — most relevant to PKLR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Kuvan® in Phenylketonuria Patients Less Than 4 Years Old	PHASE3	COMPLETED
To Assess Safety of Mitapivat and Provide Proof of Concept of the Efficacy of the Drug in Patients With RBC Membranopathies or CDAII.	PHASE2	RECRUITING
Clinical Trial to Evaluate the Efficacy of Gene Therapy for Pyruvate Kinase Deficiency	PHASE2	SUSPENDED
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors	PHASE2	ACTIVE_NOT_RECRUITING
Ketohexokinase Inhibition in NAFLD	PHASE2	COMPLETED
Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer	PHASE2	SUSPENDED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Kuvan Therapy in Phenylketonuria (PKU): The Effect of Blood Phenylalanine Concentration on Kuvan Response	PHASE2	COMPLETED
Short-term Metabolic Effects of Ketosteril® Supplemented Low Protein Diet in Pre-dialysis Chronic Kidney Disease (CKD) Patients	PHASE1/PHASE2	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease	nan	RECRUITING
Pyruvate Kinase Deficiency Epidemiological Study (PIECE)	nan	COMPLETED
Pyruvate Kinase Deficiency Global Longitudinal Registry	nan	ACTIVE_NOT_RECRUITING
Pyruvate Kinase Deficiency Natural History Study	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis	nan	COMPLETED
Alternative Substrates in the Critically Ill Subject	nan	COMPLETED
Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU)	nan	RECRUITING
The Causal Role of Ketone Bodies in Obesity-associated Disease Prevention - Combining Genetic Epidemiology With a Randomised Trial to Infer Causality	nan	COMPLETED
Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy	nan	COMPLETED
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH)	nan	COMPLETED
Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.	nan	RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Mechanistic Study of PK2 Pathway in Alleviating Perioperative Neurocognitive Disorders by Improving Neurometabolic Uncoupling	nan	NOT_YET_RECRUITING
Expression Profile of ERK5 and PKM2 Kinases in Neuroinflammatory Diseases.	nan	WITHDRAWN
Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms	nan	COMPLETED
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies	nan	RECRUITING
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
The Role of Pyruvate Kinase M2 in Growth, Invasion and Drug Resistance in Human Urothelial Carcinoma	nan	UNKNOWN
Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PKLR binder may also engage these)

Protein	Name	Similarity
P53657	—	1.000	P53657 →
P12928	—	1.000	P12928 →
Q29536	—	1.000	Q29536 →
Q92122	—	0.996	Q92122 →
P11980	—	0.994	P11980 →
P52480	—	0.993	P52480 →
Q12669	—	0.993	Q12669 →
P31865	—	0.993	P31865 →
O44006	—	0.993	O44006 →
P30616	—	0.992	P30616 →
P30615	—	0.992	P30615 →
Q6FIS9	—	0.992	Q6FIS9 →
PKM	Pyruvate kinase PKM	0.992	landscape →
P43924	—	0.992	P43924 →
Q07637	—	0.992	Q07637 →
Q5NVN0	—	0.992	Q5NVN0 →
P22360	—	0.992	P22360 →
O94122	—	0.992	O94122 →
P11974	—	0.992	P11974 →
P00548	—	0.991	P00548 →
P52489	—	0.990	P52489 →
Q42954	—	0.990	Q42954 →
Q93Z53	—	0.990	Q93Z53 →
Q27686	—	0.990	Q27686 →
O62619	—	0.990	O62619 →
P11979	—	0.990	P11979 →
Q875S4	—	0.990	Q875S4 →
A6UYL2	—	0.990	A6UYL2 →
P00549	—	0.990	P00549 →
A8NEP3	—	0.990	A8NEP3 →