⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029229 | 0.67 | — | — | |
| SCHEMBL3266710 | 0.66 | — | — | |
| SCHEMBL4395748 | 0.62 | — | — | |
| SCHEMBL6272478 | 0.61 | — | — | |
| SCHEMBL15919003 | 0.58 | — | — | |
| SCHEMBL4721785 | 0.56 | — | — | |
| SCHEMBL14830503 | 0.56 | — | — | |
| SCHEMBL7569561 | 0.49 | — | — | |
| SCHEMBL7409317 | 0.49 | — | — | |
| SCHEMBL11769613 | 0.48 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-07 | — | — | US | disclosed |
| US-6962920-B2 | Pyrimidine derivatives and methods of making and using these derivatives | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2005-11-08 | — | — | US | disclosed |
| US-20040039000-A1 | Novel pyrimidine derivatives and methods of making and using these derivatives | GANGJEE ALEEM (US) | 2004-02-26 | — | — | US | disclosed |
| US-6537999-B2 | Furopyrimidines and pyrrolopyrimidines; treating cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in immunocompromised patients. | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2003-03-25 | — | — | US | disclosed |
| US-20020052384-A1 | Novel pyrimidine derivatives and methods of making and using these derivatives | GANGJEE ALEEM (US) | 2002-05-02 | — | — | US | disclosed |
| US-6136601-A | ADJUSTED NUCLEOTIDE SEQUENCES WHICH CAN BE UTILIZED FOR THE GENERATION OF PREFERENTIAL MUTATION | EPOCH PHARMACEUTICALS, INC. (US) | 2000-10-24 | — | — | US | disclosed |
| CN-1078235-A | Medicinal compound | LILLY CO ELI (US) | 1993-11-10 | — | — | CN | disclosed |
| EP-0567223-A1 | Glutamic acid derivatives as antineoplastic agents | ELI LILLY AND COMPANY (US) | 1993-10-27 | — | — | EP | disclosed |
| US-5196424-A | Antitumor | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0119591-B1 | THIODEAZAPURINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1988-06-22 | — | — | EP | disclosed |
| EP-0089055-B1 | DEAZAPURINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1987-06-03 | — | — | EP | disclosed |
| US-4595530-A | Thiodeazapurine derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-06-17 | — | — | US | disclosed |
| US-4571423-A | Substituted 5-aminomethyl-2-acylaminopyrrolo[2,3-d]pyrimidin-4-ones | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 1986-02-18 | — | — | US | disclosed |
| EP-0119591-A1 | Thiodeazapurine derivatives | Takeda Chemical Industries, Ltd. (JP) | 1984-09-26 | — | — | EP | disclosed |
| EP-0089055-A2 | Deazapurine derivatives | Takeda Chemical Industries, Ltd. (JP) | 1983-09-21 | — | — | EP | disclosed |