Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MPL | P40238 | 2/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23618149 | 0.83 | MPL (0.55) | SMN1; SMN2MPLSCN5ANPC1RAB9A | |
| SCHEMBL23610362 | 0.82 | NPC1 (0.49) | SMN1; SMN2MPLSCN5ANPC1RAB9A | |
| SCHEMBL23618148 | 0.82 | SCN5A (0.49) | SMN1; SMN2MPLSCN5ANPC1RAB9A | |
| SCHEMBL558439 | 0.81 | ALDH1A1 (0.68) | SMN1; SMN2MPLNPC1RAB9ALMNA | |
| SCHEMBL19638111 | 0.78 | SCN5A (0.46) | SMN1; SMN2SCN5ANPC1RAB9ALMNA | |
| SCHEMBL131267 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2MPLNPC1RAB9ALMNA | |
| SCHEMBL2303869 | 0.77 | SMN1; SMN2 (0.70) | SMN1; SMN2MPLRAB9ALMNAGAA | |
| SCHEMBL28902428 | 0.74 | SMN1; SMN2 (1.00) | SMN1; SMN2MPLNPC1RAB9ALMNA | |
| SCHEMBL21484791 | 0.74 | TNK2 (0.45) | SMN1; SMN2SCN5ANPC1RAB9ALMNA | |
| SCHEMBL11480686 | 0.74 | SMN1; SMN2 (0.65) | SMN1; SMN2MPLNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970255-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Galapagos NV (BE) | 2016-01-20 | — | — | EP | claimed |
| WO-2014139882-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2014-09-18 | — | — | WO | claimed |