Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 20/20 | 0.71 |
| ▸ | CTSK | P43235 | 9/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16478368 | 0.84 | CTSC (0.50) | CTSCCTSK | |
| SCHEMBL16045001 | 0.83 | CTSC (1.00) | CTSCCTSK | |
| SCHEMBL16622364 | 0.78 | CTSC (1.00) | CTSCCTSK | |
| SCHEMBL16071155 | 0.76 | CTSC (1.00) | CTSCCTSK | |
| SCHEMBL16934689 | 0.73 | CTSC (0.59) | CTSCCTSK | |
| SCHEMBL16064483 | 0.73 | CTSC (1.00) | CTSCCTSK | |
| SCHEMBL16064606 | 0.73 | CTSC (1.00) | CTSCCTSK | |
| SCHEMBL22642987 | 0.73 | CTSC (1.00) | CTSCCTSK | |
| SCHEMBL14822395 | 0.71 | CTSC (1.00) | CTSCCTSK | |
| SCHEMBL16065019 | 0.71 | CTSC (1.00) | CTSCCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970252-A1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | Boehringer Ingelheim International GmbH (DE) | 2016-01-20 | — | — | EP | disclosed |
| US-8877775-B2 | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| WO-2014140091-A1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-18 | — | — | WO | disclosed |