Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | CCR1 | P32246 | 3/20 | 0.48 |
| ▸ | CCR5 | P51681 | 3/20 | 0.48 |
| ▸ | CCR8 | P51685 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26260016 | 0.87 | KDM4E (0.58) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL750980 | 0.81 | KDM4E (0.56) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL29765883 | 0.81 | KDM4E (0.56) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL8730491 | 0.79 | KDM4E (0.50) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL751816 | 0.79 | KDM4E (0.54) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL4620919 | 0.79 | KDM4E (0.48) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL30017935 | 0.77 | KDM4E (0.56) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL1770622 | 0.76 | KDM4E (0.46) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL18319296 | 0.76 | KDM4E (0.46) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL26774360 | 0.76 | KDM4E (0.50) | KDM4ELMNATP53SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512841-B1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2023-04-26 | — | — | EP | disclosed |
| US-11447464-B2 | Compounds with spirobifluorene-structures | MERCK PATENT GMBH (DE) | 2022-09-20 | — | — | US | disclosed |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-06-27 | — | — | US | disclosed |
| WO-2018050584-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2018-03-22 | — | — | WO | disclosed |
| US-9815746-B2 | Stereodynamic chemosensors | GEORGETOWN UNIVERSITY (US) | 2017-11-14 | — | — | US | disclosed |
| US-20160039723-A1 | STEREODYNAMIC CHEMOSENSORS | GEORGETOWN UNIVERSITY (US) | 2016-02-11 | — | — | US | disclosed |
| WO-2014144197-A1 | STEREODYNAMIC CHEMOSENSORS | GEORGETOWN UNIVERSITY (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447464-B2 | Compounds with spirobifluorene-structures | SLCO1B3, SLCO4C1, SLCO1B1 | KDM4E 4250/4885LMNA 2809/4885TP53 3935/4885 |
| US-20160039723-A1 | STEREODYNAMIC CHEMOSENSORS | ENO1, EDNRA, OPRL1 | KDM4E 4547/4885LMNA 4292/4885TP53 3460/4885 |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | SLCO1B3, SLCO4C1, SLCO1B1 | KDM4E 4250/4885LMNA 2809/4885TP53 3935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.