Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 20/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 13/20 | 0.69 |
| ▸ | FLT3 | P36888 | 6/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.69 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16047879 | 0.81 | CSF1R (1.00) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL16046696 | 0.81 | CSF1R (0.78) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL19338421 | 0.79 | CSF1R (0.59) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL16046299 | 0.77 | CSF1R (0.57) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL3492909 | 0.77 | CSF1R (0.57) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL16045598 | 0.77 | CSF1R (0.57) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL28343607 | 0.75 | CSF1R (0.60) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL16028875 | 0.75 | CSF1R (0.55) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL16047987 | 0.74 | CSF1R (0.57) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL31352514 | 0.73 | ACVR1 (0.64) | CSF1RPDGFRAFLT3PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968286-A2 | 2-AMINOPYRIMIDIN-6-ONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | Deciphera Pharmaceuticals, LLC (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014145025-A2 | 2-AMINOPYRIMIDIN-6-ONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2014-09-18 | — | — | WO | disclosed |