Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 20/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 15/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.59 |
| ▸ | FLT3 | P36888 | 7/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492909 | 0.88 | CSF1R (0.57) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL16045598 | 0.88 | CSF1R (0.57) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL16046299 | 0.88 | CSF1R (0.57) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL28343607 | 0.83 | CSF1R (0.60) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL16028875 | 0.83 | CSF1R (0.55) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL2030714 | 0.83 | CSF1R (0.52) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL29736796 | 0.83 | CSF1R (0.52) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL21425617 | 0.82 | CSF1R (0.61) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL30593942 | 0.81 | CSF1R (0.55) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL16059571 | 0.79 | CSF1R (0.69) | CSF1RPDGFRAPDGFRBFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968286-B1 | 2-AMINOPYRIMIDIN-6-ONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS LLC (US) | 2017-09-13 | — | — | EP | disclosed |