Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 13/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.80 |
| ▸ | MAPT | P10636 | 13/20 | 0.80 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.67 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.67 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16063974 | 0.85 | MAPT (0.77) | MEN1KMT2AMAPTTP53MAPK1 | |
| SCHEMBL12417168 | 0.83 | MAPT (0.82) | MEN1KMT2AMAPTTP53MAPK1 | |
| SCHEMBL16063975 | 0.83 | MAPT (0.75) | MEN1KMT2AMAPTMAPK1POLB | |
| SCHEMBL12417177 | 0.80 | MAPT (1.00) | MEN1KMT2AMAPTMAPK1POLB | |
| SCHEMBL16063976 | 0.78 | MAPT (0.71) | MEN1KMT2AMAPTMAPK1POLB | |
| SCHEMBL12204630 | 0.74 | MAPT (1.00) | MEN1KMT2AMAPTMAPK1POLB | |
| SCHEMBL13090673 | 0.74 | MAPT (0.59) | MEN1KMT2AMAPTMAPK1POLB | |
| SCHEMBL14103581 | 0.73 | MAPT (0.66) | MEN1KMT2AMAPTMAPK1POLB | |
| SCHEMBL13496998 | 0.73 | MAPT (0.75) | MEN1KMT2AMAPTMAPK1POLB | |
| SCHEMBL12204629 | 0.73 | MAPT (0.82) | MEN1KMT2AMAPTMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011578-B2 | Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2018-07-03 | — | — | US | disclosed |
| US-20180022722-A1 | Compounds for Stabilizing Ryanodine Receptors from Aberrant Levels of Calcium Release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | 2018-01-25 | — | — | US | disclosed |
| US-9725429-B2 | Furanyl-imine and thiofuranyl-imine compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2017-08-08 | — | — | US | disclosed |
| US-20160024038-A1 | Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | 2016-01-28 | — | — | US | disclosed |
| US-9102645-B2 | Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2015-08-11 | — | — | US | disclosed |
| WO-2014144654-A1 | COMPOUNDS FOR STABILIZING RYANODINE RECEPTORS FROM ABERRANT LEVELS OF CALCIUM RELEASE | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20140275112-A1 | Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022722-A1 | Compounds for Stabilizing Ryanodine Receptors from Aberrant Levels of Calcium Release | CHERP, RYR1, RYR2 | MEN1 3829/4885KMT2A 4045/4885MAPT 154/4885 |
| US-20140275112-A1 | Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release | CHERP, RYR1, RYR2 | MEN1 3829/4885KMT2A 4045/4885MAPT 154/4885 |
| US-10011578-B2 | Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | CHERP, RYR1, RYR2 | MEN1 3829/4885KMT2A 4045/4885MAPT 154/4885 |
| US-20160024038-A1 | Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release | CHERP, RYR1, RYR2 | MEN1 3829/4885KMT2A 4045/4885MAPT 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.