CHERP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to CHERP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Magnesium Administration in Liver Transplantation and Reperfusion Injury	PHASE4	COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis	PHASE2	COMPLETED
Evaluation of the Possible Safety and Efficacy of Dapagliflozin in the Prophylaxis of Doxorubicin-Induced Cardiotoxicity	PHASE2	RECRUITING
S 48168 (ARM 210) for the Treatment of RYR1-related Myopathies (RYR1-RM)	PHASE1	COMPLETED
Dose-Escalation Phase 1 Study of G-202 (Mipsagargin) in Patients With Advanced Solid Tumors	PHASE1	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Carnosine Supplementation on Quantity/Quality of Oral Salivae.	nan	UNKNOWN
Quantification of GADD34 Expression in RA	nan	COMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure	nan	UNKNOWN
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders	nan	UNKNOWN
Evaluation of A Clinical Diagnostic Test for CRDS	nan	RECRUITING
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Consequences of Mutations in the SPG7 Gene at the Heterozygous State	nan	COMPLETED
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)	nan	COMPLETED
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study	nan	RECRUITING
Recovery From 50 Eccentric Biceps Curls in Young, Untrained Men and Women	nan	COMPLETED
Tracking Neurodegeneration in Early Wolfram Syndrome	nan	COMPLETED
Role of Dairy Products in Weight Maintenance	nan	COMPLETED
Mitoquines in COPD	nan	UNKNOWN
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors	nan	UNKNOWN
Effect of Protein on Endoplasmic Reticulum Stress	nan	NOT_YET_RECRUITING
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Effects of Trehalose and Polyphenols in Vasculopathic Patients	nan	COMPLETED
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CHERP binder may also engage these)

Protein	Name	Similarity
Q8CGZ0	—	1.000	Q8CGZ0 →
Q5HZJ0	—	0.994	Q5HZJ0 →
O95104	—	0.993	O95104 →
Q2EJA0	—	0.990	Q2EJA0 →
Q1L8J7	—	0.990	Q1L8J7 →
P0CB49	—	0.990	P0CB49 →
Q9R0I7	—	0.990	Q9R0I7 →
Q9VIV2	—	0.990	Q9VIV2 →
Q9GZV5	—	0.990	Q9GZV5 →
Q9SQV1	—	0.989	Q9SQV1 →
H2LBU8	—	0.989	H2LBU8 →
Q63627	—	0.988	Q63627 →
Q9XUK2	—	0.988	Q9XUK2 →
A0A8C0NGY6	—	0.988	A0A8C0NGY6 →
Q8K0V4	—	0.988	Q8K0V4 →
YAP1	Transcriptional coactivator YAP1	0.988	landscape →
SMARCA2	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2	0.988	landscape →
Q9NRR4	—	0.988	Q9NRR4 →
P83038	—	0.988	P83038 →
Q80TZ9	—	0.988	Q80TZ9 →
P34545	—	0.987	P34545 →
P16371	—	0.987	P16371 →
PPP1R10	Serine/threonine-protein phosphatase 1 regulatory subunit 10	0.987	landscape →
O49570	—	0.987	O49570 →
Q23985	—	0.987	Q23985 →
P97868	—	0.987	P97868 →
O70441	—	0.987	O70441 →
Q7YR38	—	0.987	Q7YR38 →
J9VND4	—	0.987	J9VND4 →
Q6P4S6	—	0.987	Q6P4S6 →