Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16136333 | 0.85 | KDM4E (0.44) | KDM4EMAPTCYP3A4GAAALDH1A1 | |
| SCHEMBL19413334 | 0.82 | POLB (0.43) | KDM4EMAPTCYP3A4HPGDLMNA | |
| SCHEMBL4959700 | 0.74 | KDM4E (0.55) | KDM4EMAPTCYP3A4GAAALDH1A1 | |
| SCHEMBL1566538 | 0.71 | KDM4E (0.55) | KDM4EMAPTCYP3A4GAAALDH1A1 | |
| SCHEMBL27707292 | 0.71 | KDM4E (0.55) | KDM4EMAPTCYP3A4GAAALDH1A1 | |
| SCHEMBL27554380 | 0.71 | KDM4E (0.55) | KDM4EMAPTCYP3A4GAAALDH1A1 | |
| SCHEMBL18381316 | 0.70 | LMNA (0.50) | MAPTTSHRMEN1KMT2ALMNA | |
| SCHEMBL1949484 | 0.69 | KDM4E (0.53) | KDM4EMAPTCYP3A4GAAALDH1A1 | |
| SCHEMBL6503518 | 0.67 | KDM4E (0.55) | KDM4EMAPTCYP3A4GAAALDH1A1 | |
| SCHEMBL27634016 | 0.67 | KDM4E (0.55) | KDM4EMAPTCYP3A4GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014144747-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2014-09-18 | — | — | WO | disclosed |