SCHEMBL16066482

SCHEMBL16066482

C[Si](C)(C)c1ccc(-c2cc(-c3ccc([Si](C)(C)C)cc3)nc(-n3c4ccccc4c4ccc5c(c6ccccc6n6c7ccccc7nc56)c43)n2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.39
KDM4E B2RXH2 4/20 0.39
POLB P06746 2/20 0.39
LMNA P02545 1/20 0.39
TP53 P04637 1/20 0.39
HSD17B10 Q99714 1/20 0.39
ALDH1A1 P00352 4/20 0.37
HPGD P15428 4/20 0.37
FLT3 P36888 6/20 0.37
KMT2A Q03164 5/20 0.35
MEN1 O00255 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
CAMKK1 Q8N5S9 2/20 0.34
CAMKK2 Q96RR4 2/20 0.34
BMX P51813 2/20 0.34
BCL2 P10415 1/20 0.34
CSNK2A2 P19784 1/20 0.34
CSNK2B P67870 1/20 0.34
CSNK2A1 P68400 1/20 0.34
PIM3 Q86V86 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16066672 0.91 MAPT (0.38) MAPTKDM4EPOLBLMNATP53
SCHEMBL16066530 0.90 HPGD (0.43) MAPTKDM4EPOLBLMNATP53
SCHEMBL16066375 0.90 HPGD (0.45) MAPTKDM4EPOLBLMNATP53
SCHEMBL16066800 0.89 MAPT (0.39) MAPTKDM4EPOLBLMNATP53
SCHEMBL16066182 0.89 KDM4E (0.41) MAPTKDM4EPOLBLMNATP53
SCHEMBL16066476 0.88 ALDH1A1 (0.48) MAPTKDM4EPOLBLMNATP53
SCHEMBL16066626 0.86 MAPT (0.39) MAPTKDM4EPOLBLMNATP53
SCHEMBL16066481 0.86 DHODH (0.39) MAPTKDM4EPOLBLMNATP53
SCHEMBL16066971 0.84 KDM4E (0.40) MAPTKDM4EPOLBLMNATP53
SCHEMBL16066417 0.84 KDM4E (0.42) MAPTKDM4EPOLBLMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014142488-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT INCLUDING SAME 주식회사 두산 (KR) 2014-09-18 WO disclosed