Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 14/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 14/20 | 0.56 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.51 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.51 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.51 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16068261 | 0.83 | KEAP1 (0.53) | KEAP1NFE2L2PRMT5MEN1KMT2A | |
| SCHEMBL27088356 | 0.81 | KEAP1 (0.62) | KEAP1NFE2L2PRMT5MEN1KMT2A | |
| SCHEMBL16068165 | 0.80 | TEK (0.53) | PRMT5HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20673795 | 0.79 | HDAC8 (0.64) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL29965678 | 0.79 | HDAC8 (0.50) | SSTR2SSTR5HDAC3HDAC4HDAC1 | |
| SCHEMBL16169650 | 0.79 | HDAC8 (0.50) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL28605137 | 0.78 | MEN1 (0.65) | KEAP1NFE2L2PRMT5MEN1KMT2A | |
| SCHEMBL17517592 | 0.77 | HDAC8 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5287307 | 0.76 | HDAC8 (0.61) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19309771 | 0.76 | HDAC6 (0.49) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200040024-A1 | CONVERGENT PROCESSES FOR PREPARING MACROLIDE ANTIBACTERIAL AGENTS | Têtard, Inc. (US) | 2020-02-06 | — | — | US | disclosed |
| US-20190023731-A1 | CONVERGENT PROCESSES FOR PREPARING MACROLIDE ANTIBACTERIAL AGENTS | TETARD, INC. | 2019-01-24 | — | — | US | disclosed |
| US-9751908-B2 | Convergent processes for preparing macrolide antibacterial agents | CEMPRA PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9751908-B2 | Convergent processes for preparing macrolide antibacterial agents | CEMPRA PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20160046660-A1 | CONVERGENT PROCESSES FOR PREPARING MACROLIDE ANTIBACTERIAL AGENTS | TETARD, INC. | 2016-02-18 | — | — | US | disclosed |
| US-20160046660-A1 | CONVERGENT PROCESSES FOR PREPARING MACROLIDE ANTIBACTERIAL AGENTS | TETARD, INC. | 2016-02-18 | — | — | US | disclosed |
| WO-2014145210-A1 | CONVERGENT PROCESSES FOR PREPARING MACROLIDE ANTIBACTERIAL AGENTS | CEMPRA PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046660-A1 | CONVERGENT PROCESSES FOR PREPARING MACROLIDE ANTIBACTERIAL AGENTS | COASY, TKT, CYP51A1 | KEAP1 2618/4885NFE2L2 4196/4885SSTR1 1485/4885 |
| US-20190023731-A1 | CONVERGENT PROCESSES FOR PREPARING MACROLIDE ANTIBACTERIAL AGENTS | COASY, TKT, CYP51A1 | KEAP1 2618/4885NFE2L2 4196/4885SSTR1 1485/4885 |
| US-20200040024-A1 | CONVERGENT PROCESSES FOR PREPARING MACROLIDE ANTIBACTERIAL AGENTS | COASY, TKT, CYP51A1 | KEAP1 2618/4885NFE2L2 4196/4885SSTR1 1485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.