Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 12/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 12/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 12/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 11/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 9/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 9/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 9/20 | 0.41 |
| ▸ | TFDP2 | Q14188 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16069463 | 0.90 | PRKAG1 (0.44) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 | |
| SCHEMBL17391625 | 0.88 | PRKAG1 (0.41) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 | |
| SCHEMBL16069464 | 0.87 | PRKAG1 (0.54) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 | |
| SCHEMBL16069469 | 0.85 | PRKAG1 (0.42) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 | |
| SCHEMBL16069459 | 0.84 | PRKAG1 (0.47) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 | |
| SCHEMBL16069468 | 0.84 | PRKAG1 (0.55) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 | |
| SCHEMBL16069888 | 0.83 | PRKAG1 (0.52) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 | |
| SCHEMBL23967734 | 0.82 | PRKAG1 (0.40) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 | |
| SCHEMBL17391551 | 0.82 | CNR1 (0.40) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 | |
| SCHEMBL23967736 | 0.82 | PRKAG1 (0.41) | PRKAG1PRKAA2PRKAB1PRKAA1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014139388-A1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME CORP. (US) | 2014-09-18 | — | — | WO | disclosed |