Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 7/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17470200 | 0.91 | FGFR3 (0.44) | FGFR1FGFR4KDRLCKMAPK14 | |
| SCHEMBL16050076 | 0.91 | FGFR1 (0.49) | FGFR1FGFR4BRD4KDRALK | |
| SCHEMBL17470087 | 0.90 | FGFR1 (0.46) | FGFR1BRD4KDRLCKMAPK14 | |
| SCHEMBL19101625 | 0.86 | FGFR4 (0.39) | FGFR1FGFR4BRD4KDRLCK | |
| SCHEMBL16070188 | 0.84 | FGFR4 (0.43) | FGFR1FGFR4PTK2 | |
| SCHEMBL16050206 | 0.82 | FGFR1 (0.51) | FGFR1FGFR4BRD4KDRALK | |
| SCHEMBL16050007 | 0.82 | FGFR1 (0.51) | FGFR1FGFR4BRD4KDRALK | |
| SCHEMBL17470090 | 0.82 | FGFR3 (0.46) | FGFR1FGFR4KDRLCKMAPK14 | |
| SCHEMBL16070240 | 0.81 | FGFR4 (0.44) | FGFR1FGFR4PTK2 | |
| SCHEMBL16069924 | 0.81 | FGFR4 (0.44) | FGFR1FGFR4KDRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701680-B2 | Pyrimidine and pyridine compounds and their usage | HUTCHISON MEDIPHARMA LIMITED (CN) | 2017-07-11 | — | — | US | disclosed |
| US-20160024021-A1 | NOVEL PYRIMIDINE AND PYRIDINE COMPOUNDS AND THEIR USAGE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2016-01-28 | — | — | US | disclosed |
| WO-2014139465-A1 | NOVEL PYRIMIDINE AND PYRIDINE COMPOUNDS AND THEIR USAGE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024021-A1 | NOVEL PYRIMIDINE AND PYRIDINE COMPOUNDS AND THEIR USAGE | FGFR3, FGFR1, FGFR4 | FGFR1 2/4885FGFR4 3/4885BRD4 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.