Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.60 |
| ▸ | JAK2 | O60674 | 8/20 | 0.60 |
| ▸ | ITK | Q08881 | 5/20 | 0.60 |
| ▸ | TYK2 | P29597 | 5/20 | 0.60 |
| ▸ | AURKA | O14965 | 5/20 | 0.60 |
| ▸ | SYK | P43405 | 5/20 | 0.60 |
| ▸ | EGFR | P00533 | 4/20 | 0.60 |
| ▸ | PLK4 | O00444 | 4/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.60 |
| ▸ | PAK4 | O96013 | 4/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.60 |
| ▸ | INSR | P06213 | 4/20 | 0.60 |
| ▸ | LCK | P06239 | 4/20 | 0.60 |
| ▸ | FYN | P06241 | 4/20 | 0.60 |
| ▸ | LYN | P07948 | 4/20 | 0.60 |
| ▸ | RET | P07949 | 4/20 | 0.60 |
| ▸ | ROS1 | P08922 | 4/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.60 |
| ▸ | SRC | P12931 | 4/20 | 0.60 |
| ▸ | FLT1 | P17948 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1474672 | 1.00 | JAK3 (0.60) | JAK3JAK2ITKTYK2AURKA | |
| SCHEMBL1275642 | 0.92 | SYK (0.72) | JAK3JAK2ITKTYK2AURKA | |
| SCHEMBL1474409 | 0.92 | STK17A (0.57) | JAK3JAK2ITKTYK2AURKA | |
| SCHEMBL4002770 | 0.90 | JAK3 (0.62) | JAK3JAK2ITKTYK2AURKA | |
| SCHEMBL1474614 | 0.90 | SYK (0.56) | JAK3JAK2ITKTYK2AURKA | |
| SCHEMBL1475626 | 0.89 | CDK1 (0.57) | JAK3JAK2ITKTYK2AURKA | |
| SCHEMBL1606869 | 0.89 | CDK1 (0.57) | JAK3JAK2ITKTYK2AURKA | |
| SCHEMBL1474685 | 0.89 | CA2 (0.60) | JAK3JAK2ITKTYK2AURKA | |
| SCHEMBL1474744 | 0.88 | EGFR (0.54) | JAK3JAK2ITKTYK2AURKA | |
| SCHEMBL1474824 | 0.88 | JAK3 (0.74) | JAK3JAK2ITKTYK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304422-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-06 | — | — | US | claimed |
| US-7947698-B2 | Prevent trabsplant rejection; autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | claimed |
| US-20110082146-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | claimed |
| US-20080279867-A1 | Prevent trabsplant rejection; autoimmune diseases | RIGEL PHARMACEUTICALS, INC. | 2008-11-13 | — | — | US | claimed |
| WO-2008118822-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2008-10-02 | — | — | WO | claimed |
| US-8304422-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| US-7947698-B2 | Prevent trabsplant rejection; autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20110082146-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
| US-20080279867-A1 | Prevent trabsplant rejection; autoimmune diseases | RIGEL PHARMACEUTICALS, INC. | 2008-11-13 | — | — | US | disclosed |
| WO-2008118822-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082146-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | JAK3 1/4885JAK2 2/4885ITK 637/4885 |
| US-20080279867-A1 | Prevent trabsplant rejection; autoimmune diseases | JAK3, JAK1, JAK2 | JAK3 1/4885JAK2 3/4885ITK 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.