⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479399 | 1.00 | ALOX15 (1.00) | — | |
| SCHEMBL7913 | 1.00 | — | — | |
| Benzene SCHEMBL27362418 | 0.97 | ALOX15 (0.94) | — | |
| SCHEMBL28125487 | 0.97 | ALOX15 (0.94) | — | |
| Water SCHEMBL27537650 | 0.97 | ALOX15 (0.94) | — | |
| Ammonia Solution, Strong SCHEMBL28553518 | 0.97 | ALOX15 (0.94) | — | |
| Water SCHEMBL27508265 | 0.97 | ALOX15 (0.94) | — | |
| Hydrochloric Acid SCHEMBL5186835 | 0.97 | ALOX15 (0.94) | — | |
| Bromide SCHEMBL3911094 | 0.97 | ALOX15 (0.94) | — | |
| SCHEMBL28162592 | 0.97 | ALOX15 (0.94) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6627626-B2 | Antiinflammation agents and antiarthritic agents colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals. | PFIZER INC. | 2003-09-30 | — | — | US | claimed |
| US-20030144279-A1 | 5-Heterocyclo-pyrazoles | MINICH MARTHA L (US) | 2003-07-31 | — | — | US | claimed |
| WO-2003037352-A1 | 1-PHENYL-5-N-HETEROCYCLYL-PYRAZOLES AS CYCLOOXYGENASE INHIBITORS FOR THE TREATMENT OF INFLAMMATION ASSOCIATED DISORDERS | PFIZER PRODUCTS INC. (US) | 2003-05-08 | — | — | WO | claimed |
| EP-1308161-A1 | 5-N-heterocyclyl-1-(4-sulfonyl-phenyl)-1H-pyrazole derivatives with cyclooxygenase 2 (COX-2) inhibiting activity for the treatment of inflammatory diseases | Pfizer Products Inc. (US) | 2003-05-07 | — | — | EP | claimed |
| EP-0751944-B1 | THIAZOLIDINES AND OXAZOLIDINES SUBSTITUTED BY A PYRIDINE RING AND THEIR USE AS HYPOGLYCEMIC AGENTS | NISSAN CHEMICAL IND LTD (JP) | 2000-12-20 | — | — | EP | claimed |
| CN-112689634-B | SMAD3 inhibitors | 莫扎制药有限公司 | 2024-07-16 | — | — | CN | disclosed |
| US-12024536-B2 | C-terminal HSP90 inhibitors | UNIVERSITY OF KANSAS (US) | 2024-07-02 | — | — | US | disclosed |
| US-20230277534-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2023-09-07 | — | — | US | disclosed |
| CN-111662330-B | Substituted 4-phenylpyridines for the treatment of NK-1 receptor related diseases | 赫尔森保健股份公司 | 2023-05-12 | — | — | CN | disclosed |
| US-20230102047-A1 | C-TERMINAL HSP90 INHIBITORS | REATA PHARMACEUTICALS, INC. | 2023-03-30 | — | — | US | disclosed |
| US-11390640-B2 | C-terminal Hsp90 inhibitors | UNIVERSITY OF KANSAS (US) | 2022-07-19 | — | — | US | disclosed |
| US-11337976-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2022-05-24 | — | — | US | disclosed |
| WO-2003037352-A1 | 1-PHENYL-5-N-HETEROCYCLYL-PYRAZOLES AS CYCLOOXYGENASE INHIBITORS FOR THE TREATMENT OF INFLAMMATION ASSOCIATED DISORDERS | PFIZER PRODUCTS INC. (US) | 2003-05-08 | — | — | WO | disclosed |
| EP-1308161-A1 | 5-N-heterocyclyl-1-(4-sulfonyl-phenyl)-1H-pyrazole derivatives with cyclooxygenase 2 (COX-2) inhibiting activity for the treatment of inflammatory diseases | Pfizer Products Inc. (US) | 2003-05-07 | — | — | EP | disclosed |
| US-6531492-B1 | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents | PFIZER INC. | 2003-03-11 | — | — | US | disclosed |
| EP-1273576-A1 | Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents | Pfizer Products Inc. (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1273582-A1 | Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents | Pfizer Products Inc. (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1273580-A1 | Sulfonyl heteroaryl triazoles as anti-inflammatory and analgesic agents | Pfizer Products Inc. (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1233959-A1 | HETEROCYCLO-ALKYLSULFONYL PYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | Pfizer Products Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001040216-A1 | HETEROCYCLO-ALKYLSULFONYL PYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | disclosed |