Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881147 | 0.95 | GAA (0.32) | KCNH2HRH3 | |
| SCHEMBL8139831 | 0.71 | CEL (0.32) | — | |
| SCHEMBL1606647 | 0.71 | CEL (0.32) | — | |
| SCHEMBL1608176 | 0.68 | KCNH2 (0.31) | KCNH2HRH3 | |
| SCHEMBL533376 | 0.66 | KCNH2 (0.43) | KCNH2HRH3 | |
| SCHEMBL1607566 | 0.66 | HRH1 (0.32) | KCNH2HRH3 | |
| SCHEMBL28785738 | 0.66 | KCNH2 (0.35) | KCNH2HRH3 | |
| SCHEMBL9827581 | 0.66 | NR1I2 (0.38) | KCNH2HRH3 | |
| SCHEMBL9396417 | 0.66 | HSD17B10 (0.39) | — | |
| SCHEMBL16031738 | 0.64 | KCNH2 (0.31) | KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518975-B2 | Gamma secretase modulators | Merck Sharp + Dohme Corp. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20110082153-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION | 2011-04-07 | — | — | US | disclosed |
| EP-2200990-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009032277-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082153-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | KCNH2 4241/4885HRH3 2948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.