Sugi Predict

Sugi Predict / Targets / CEL

CEL

Bile salt-activated lipase · P19835 · CEL on Sugi Atlas →

1,951 patent compounds predicted against CEL, 262 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL6657095 SCHEMBL6657095 1.00 7/20
SCHEMBL3761170 SCHEMBL3761170 0.58 6/20
SCHEMBL9133794 SCHEMBL9133794 0.55 4/20
SCHEMBL16058671 SCHEMBL16058671 0.50 4/20
SCHEMBL6653211 SCHEMBL6653211 0.46 4/20
SCHEMBL11853675 SCHEMBL11853675 0.46 4/20
SCHEMBL7261871 SCHEMBL7261871 0.42 4/20
SCHEMBL18626660 SCHEMBL18626660 0.41 4/20
Decarboxylated Derivative Decarboxylated Derivative (SCHEMBL7091208) 0.37 4/20
SCHEMBL11756678 SCHEMBL11756678 0.36 4/20
SCHEMBL4171525 SCHEMBL4171525 0.33 4/20
SCHEMBL13059860 SCHEMBL13059860 0.53 3/20
SCHEMBL1733071 SCHEMBL1733071 0.51 3/20
SCHEMBL4358424 SCHEMBL4358424 0.40 3/20
SCHEMBL6518515 SCHEMBL6518515 0.40 3/20
SCHEMBL6522113 SCHEMBL6522113 0.40 3/20
SCHEMBL6523849 SCHEMBL6523849 0.40 3/20
SCHEMBL6525950 SCHEMBL6525950 0.40 3/20
SCHEMBL11856309 SCHEMBL11856309 0.40 3/20
SCHEMBL903655 SCHEMBL903655 0.39 3/20

Clinical trials — most relevant to CEL by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency PHASE4RECRUITING
Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons PHASE4COMPLETED
SOLUTION: Study of Oral Liprotamase Unit-Matched Therapy Of Non-Porcine Origin in Patients With Cystic Fibrosis PHASE3COMPLETED
Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis PHASE3COMPLETED
Aggressive Fluid Hydration for the Prevention of Post-ERCP Pancreatitis PHASE3COMPLETED
A Mechanistic Study of the Effects of LY518674 on High-Density Lipoprotein Cholesterol (HDL-C) Metabolism PHASE2COMPLETED
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis PHASE2ACTIVE_NOT_RECRUITING
Ability of a Tea Leaf Extracts Preparation to Slow Down Carbohydrate and Fat Absorption PHASE1COMPLETED
Effects of FXR Activation on Hepatic Lipid and Glucose Metabolism EARLY_PHASE1COMPLETED
Study Comparing Blood Levels of Fatty Acids After Consuming Two Forms of Cod Liver Oil nanCOMPLETED
Acute Pancreatitis Targets (APT) Study nanCOMPLETED
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL) nanCOMPLETED
A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB nanRECRUITING
Effects of Lipids on Gastric Emptying, Satiety Hormones, and Appetite in Severe Overweight nanCOMPLETED
A 90 Day Observational Study as an Extension to the Phase 3,Open Labeled Exploratory Study of RELiZORB nanENROLLING_BY_INVITATION
Effect of Molecular Hydrogen in Patients With NAFLD nanCOMPLETED
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study. nanRECRUITING
Study of Fat Malabsorption by Lipiblock Versus Xenical nanCOMPLETED
An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype nanCOMPLETED
Microbial Enzyme Impact on Postprandial Nutrient Levels and Gastrointestinal Symptoms in Healthy Adults nanCOMPLETED
Hypertriglyceridemia-associated Acute Pancreatitis: Apheresis Vs. Conservative Treatment nanCOMPLETED
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism nanCOMPLETED
Prospective Study in Pelvic Radiotherapy Patients nanCOMPLETED
Impact of External Drainage of the Main Pancreatic Duct and Common Bile Duct on Pancreatic Fistula Following Pancreaticoduodenectomy nanRECRUITING
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose nanCOMPLETED
Effects of Colesevelam HCl On Bile Acid Kinetics nanCOMPLETED
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans nanCOMPLETED
Nutrition Intervention for Pancreatic Cancer nanRECRUITING
Association Between HDL Functions and Atherosclerotic Burden in Healthy Individuals nanCOMPLETED
The Evaluation of Pro/Antioxidative Profile and Diagnostic Parameters in the Patients With Pancreatic Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CEL binder may also engage these)

ProteinNameSimilarity
P07882 — 0.985 P07882 →
P30122 — 0.984 P30122 →
Q64285 — 0.981 Q64285 →
CES1 Liver carboxylesterase 1 0.978 landscape →
O46421 — 0.978 O46421 →
Q63010 — 0.978 Q63010 →
Q64176 — 0.978 Q64176 →
Q29550 — 0.977 Q29550 →
Q8VCC2 — 0.977 Q8VCC2 →
P41245 — 0.977 P41245 →
Q27677 — 0.976 Q27677 →
Q8VCT4 — 0.976 Q8VCT4 →
Q63108 — 0.976 Q63108 →
Q04456 — 0.976 Q04456 →
Q9DDE3 — 0.975 Q9DDE3 →
P10959 — 0.975 P10959 →
Q5GRG2 — 0.975 Q5GRG2 →
Q64573 — 0.975 Q64573 →
Q86GC8 — 0.975 Q86GC8 →
W4VSJ0 — 0.975 W4VSJ0 →
Q04457 — 0.975 Q04457 →
Q91WU0 — 0.974 Q91WU0 →
Q8VCU1 — 0.974 Q8VCU1 →
P23953 — 0.974 P23953 →
P32749 — 0.974 P32749 →
Q63880 — 0.974 Q63880 →
Q8R0W5 — 0.974 Q8R0W5 →
O16171 — 0.974 O16171 →
P16303 — 0.973 P16303 →
P56161 — 0.973 P56161 →