Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16031127 | 1.00 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16031124 | 1.00 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16031911 | 1.00 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16148653 | 1.00 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL20144830 | 0.83 | HCRTR2 (0.71) | HCRTR2HCRTR1 | |
| SCHEMBL18697564 | 0.83 | HCRTR2 (0.71) | HCRTR2HCRTR1 | |
| SCHEMBL16078140 | 0.82 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16030314 | 0.82 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16031262 | 0.82 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16149373 | 0.82 | HCRTR2 (1.00) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |
| US-9611251-B2 | Substituted piperidine compounds and their use as orexin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-04 | — | — | US | disclosed |
| US-9611251-B2 | Substituted piperidine compounds and their use as orexin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-04 | — | — | US | disclosed |
| US-20160046599-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-18 | — | — | US | disclosed |
| US-20160046599-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-18 | — | — | US | disclosed |
| US-9115117-B2 | Substituted piperidine compounds and their use as orexin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-08-25 | — | — | US | disclosed |
| US-9115117-B2 | Substituted piperidine compounds and their use as orexin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-08-25 | — | — | US | disclosed |
| WO-2014165065-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-10-09 | — | — | WO | disclosed |
| US-20140275095-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275095-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | HCRTR2, HCRTR1, NPY1R | HCRTR2 1/4885HCRTR1 2/4885 |
| US-20160046599-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | HCRTR2, HCRTR1, NPY1R | HCRTR2 1/4885HCRTR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.