Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 9/20 | 0.71 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.48 |
| ▸ | CCNK | O75909 | 3/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18697564 | 1.00 | HCRTR2 (0.71) | HCRTR2PDE2ACDK12CCNKMAPK8 | |
| SCHEMBL16031911 | 0.83 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16031124 | 0.83 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16031127 | 0.83 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16078142 | 0.83 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16148653 | 0.83 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL20144881 | 0.80 | HCRTR2 (0.68) | HCRTR2CDK12CCNKHCRTR1 | |
| SCHEMBL20144958 | 0.79 | HCRTR2 (0.69) | HCRTR2PDE2AHCRTR1 | |
| SCHEMBL18697565 | 0.79 | HCRTR2 (0.69) | HCRTR2PDE2AHCRTR1 | |
| SCHEMBL4241004 | 0.78 | HCRTR2 (0.59) | HCRTR2CDK12CCNKMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |