Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCKDK | O14874 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 7/20 | 0.39 |
| ▸ | PHOSPHO1 | Q8TCT1 | 5/20 | 0.39 |
| ▸ | PMM2 | O15305 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | G6PD | P11413 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2614663 | 0.83 | CYP17A1 (0.42) | MPIPHOSPHO1PMM2RAB9AG6PD | |
| SCHEMBL13810651 | 0.83 | BCKDK (0.42) | BCKDKALDH1A1LMNAMAPTPOLB | |
| SCHEMBL13809848 | 0.80 | BCKDK (0.47) | BCKDKALDH1A1LMNAMAPTPOLB | |
| SCHEMBL12310725 | 0.80 | BCKDK (0.56) | BCKDKALDH1A1LMNAMAPTPOLB | |
| SCHEMBL16284423 | 0.80 | BCKDK (0.40) | BCKDKALDH1A1LMNAMAPTPOLB | |
| SCHEMBL13713801 | 0.78 | BCL2L1 (0.44) | ALDH1A1LMNAMAPTRAB9AKDM4E | |
| SCHEMBL16075899 | 0.77 | BCKDK (0.38) | BCKDKALDH1A1LMNAMAPTPOLB | |
| SCHEMBL12922994 | 0.77 | BCKDK (0.38) | BCKDKALDH1A1LMNAMAPTPOLB | |
| SCHEMBL16284427 | 0.76 | BCKDK (0.41) | BCKDKALDH1A1LMNAMAPTPOLB | |
| SCHEMBL12095255 | 0.76 | BCKDK (0.41) | BCKDKALDH1A1LMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275031-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE CORPORATION (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275031-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | JAK1, JAK2, JAK3 | BCKDK 4303/4885ALDH1A1 1457/4885LMNA 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.