BCKDK — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL594468	1.00	2/20
SCHEMBL6886010	1.00	2/20
Hydrochloric Acid (SCHEMBL11394582)	0.97	2/20
SCHEMBL2279755	0.77	2/20
SCHEMBL2723054	0.75	2/20
SCHEMBL2610278	0.74	2/20
SCHEMBL25735859	0.73	2/20
SCHEMBL31053391	0.71	2/20
SCHEMBL417349	0.71	2/20
SCHEMBL11684474	0.71	2/20
SCHEMBL12153769	0.71	2/20
SCHEMBL18050231	0.71	2/20
SCHEMBL20559686	0.71	2/20
Hydrochloric Acid (SCHEMBL10855356)	0.69	2/20
Hydrochloric Acid (SCHEMBL11398368)	0.69	2/20
SCHEMBL693146	0.68	2/20
SCHEMBL13659611	0.68	2/20
SCHEMBL2895162	0.67	2/20
SCHEMBL2960466	0.67	2/20
SCHEMBL5453267	0.67	2/20

Clinical trials — most relevant to BCKDK by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phenylbutyrate Therapy for Maple Syrup Urine Disease	PHASE2/PHASE3	COMPLETED
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:	PHASE3	ACTIVE_NOT_RECRUITING
Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis	PHASE3	COMPLETED
Exogenous Ketone Esters for Refractory Status Epileptics	PHASE2/PHASE3	RECRUITING
Ketogenic Diet vs ACTH for the Treatment of Children With West Syndrome	PHASE2/PHASE3	ACTIVE_NOT_RECRUITING
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Effects of Experimental Hyperketonemia on Myocardial Metabolism	EARLY_PHASE1	COMPLETED
Evaluation of Hydroxymethylbutyrate Supplementation in Lung Transplant Candidates Receiving Pulmonary Rehabilitation	nan	COMPLETED
Alternative Substrates in the Critically Ill Subject	nan	COMPLETED
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy	nan	UNKNOWN
Pyruvate Kinase Deficiency Natural History Study	nan	COMPLETED
Longitudinal Study of Mitochondrial Hepatopathies	nan	SUSPENDED
Mitochondrial Assessment in Critical Ill Patients in Intensive Care	nan	NOT_YET_RECRUITING
Effects of Exogenous Ketosis on Proteinuria and Renal Function	nan	RECRUITING
The Ketogenic Diet in the Treatment of Behavioral Variant Frontotemporal Dementia	nan	NOT_YET_RECRUITING
Ketogenic Diet and Prostate Cancer Surveillance Pilot	nan	COMPLETED
Androgens and NAFLD Longitudinal Cohort Study	nan	RECRUITING
Pyruvate Kinase Deficiency Global Longitudinal Registry	nan	ACTIVE_NOT_RECRUITING
Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU)	nan	RECRUITING
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
PANDA: PKU Amino Acid Evaluation	nan	COMPLETED
Energy Expenditure and Quality of Life in Epilepsy	nan	WITHDRAWN
The Ketogenic Diet in the Treatment of Alzheimer's Disease	nan	COMPLETED
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies	nan	RECRUITING
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure	nan	UNKNOWN
Genetic and Metabolic Disease in Children	nan	RECRUITING
The Effect of Raising Ketones Directly With MCT Oil on Inflammation in Healthy Young Adults	nan	COMPLETED
MyRareDiet A Novel Diet Tracking Tool	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a BCKDK binder may also engage these)

Protein	Name	Similarity
Q2KJG8	—	1.000	Q2KJG8 →
O55028	—	1.000	O55028 →
Q00972	—	1.000	Q00972 →
O70571	—	0.999	O70571 →
Q1KMR4	—	0.999	Q1KMR4 →
Q64536	—	0.998	Q64536 →
Q9JK42	—	0.998	Q9JK42 →
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0.997	landscape →
O02623	—	0.995	O02623 →
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0.995	landscape →
Q63065	—	0.995	Q63065 →
Q02332	—	0.994	Q02332 →
Q8BFP9	—	0.994	Q8BFP9 →
O88345	—	0.992	O88345 →
PDK4	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0.991	landscape →
O54937	—	0.991	O54937 →
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0.990	landscape →
Q922H2	—	0.990	Q922H2 →
P40530	—	0.989	P40530 →
P91622	—	0.989	P91622 →
Q9P6P9	—	0.989	Q9P6P9 →
B6JWC1	—	0.988	B6JWC1 →
Q8TGA1	—	0.988	Q8TGA1 →
Q9UUI7	—	0.987	Q9UUI7 →
P78875	—	0.986	P78875 →
A5D7Q3	—	0.986	A5D7Q3 →
Q9P7P0	—	0.986	Q9P7P0 →
C4JF81	—	0.985	C4JF81 →
A0A411KUP9	—	0.985	A0A411KUP9 →
Q751P7	—	0.985	Q751P7 →